| pubmed-article:11230330 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11230330 | lifeskim:mentions | umls-concept:C0001811 | lld:lifeskim |
| pubmed-article:11230330 | lifeskim:mentions | umls-concept:C0020538 | lld:lifeskim |
| pubmed-article:11230330 | lifeskim:mentions | umls-concept:C0014257 | lld:lifeskim |
| pubmed-article:11230330 | lifeskim:mentions | umls-concept:C0038836 | lld:lifeskim |
| pubmed-article:11230330 | lifeskim:mentions | umls-concept:C0277785 | lld:lifeskim |
| pubmed-article:11230330 | lifeskim:mentions | umls-concept:C1979886 | lld:lifeskim |
| pubmed-article:11230330 | lifeskim:mentions | umls-concept:C1524003 | lld:lifeskim |
| pubmed-article:11230330 | lifeskim:mentions | umls-concept:C0205214 | lld:lifeskim |
| pubmed-article:11230330 | pubmed:issue | 2 Part 2 | lld:pubmed |
| pubmed-article:11230330 | pubmed:dateCreated | 2001-3-20 | lld:pubmed |
| pubmed-article:11230330 | pubmed:abstractText | There is evidence in humans that hypertension and aging similarly impair endothelial function, although the mechanism remains unclear. Superoxide anion (O(2)(-)) is a major determinant of nitric oxide (NO) bioavailability and thus endothelial function. We sought to determine the relationship between endothelial function, O(2)(-), and age in normotensive Wistar-Kyoto (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP). Aortic rings were removed from female WKY and SHRSP at 3 to 4 months (young) and 9 to 12 months (old). O(2)(-) generation by aortic rings was measured before and after removal of the endothelium or incubation with N(G) nitro-L-arginine methyl ester, diphenyleneiodonium, or apocynin. Levels of p22phox were studied with immunohistochemistry and used as a marker of NAD(P)H oxidase expression. NO bioavailability was significantly lower in old WKY compared with young WKY (P=0.0009) and in old SHRSP compared with young SHRSP (P=0.005). O(2)(-) generation was significantly greater in old WKY compared with young WKY (P=0.0001). Removal of the endothelium and N(G) nitro-L-arginine methyl ester treatment resulted in a significant reduction in O(2)(-) generation in old SHRSP (P=0.009 and 0.001, respectively). Diphenyleneiodonium significantly reduced O(2)(-) generation in 12-month WKY (P=0.008) and 12-month SHRSP (P=0.009). Apocynin attenuated O(2)(-) generation by older WKY (P=0.038) and SHRSP (P=0.028). p22phox was increased in older animals compared with young. We conclude that NO bioavailability decreases with age in female WKY and SHRSP. O(2)(-) generation increases with age in WKY and is higher in SHRSP and may contribute to the reduced NO by scavenging. NAD(P)H oxidase may contribute to the age-related increase in O(2)(-). | lld:pubmed |
| pubmed-article:11230330 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11230330 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11230330 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11230330 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11230330 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11230330 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11230330 | pubmed:issn | 1524-4563 | lld:pubmed |
| pubmed-article:11230330 | pubmed:author | pubmed-author:HamiltonC ACA | lld:pubmed |
| pubmed-article:11230330 | pubmed:author | pubmed-author:GrahamDD | lld:pubmed |
| pubmed-article:11230330 | pubmed:author | pubmed-author:McIntyreMM | lld:pubmed |
| pubmed-article:11230330 | pubmed:author | pubmed-author:DominiczakA... | lld:pubmed |
| pubmed-article:11230330 | pubmed:author | pubmed-author:BrosnanM JMJ | lld:pubmed |
| pubmed-article:11230330 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:11230330 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:11230330 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11230330 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11230330 | pubmed:pagination | 529-34 | lld:pubmed |
| pubmed-article:11230330 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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| pubmed-article:11230330 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11230330 | pubmed:articleTitle | Superoxide excess in hypertension and aging: a common cause of endothelial dysfunction. | lld:pubmed |
| pubmed-article:11230330 | pubmed:affiliation | Department of Medicine and Therapeutics, Western Infirmary, Glasgow, UK. cah1p@clinmed.gla.ac.uk | lld:pubmed |
| pubmed-article:11230330 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11230330 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:11230330 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:11230330 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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