|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2001-3-2
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|
pubmed:abstractText |
Replication of human immunodeficiency virus type 1 (HIV-1) requires specific interactions of Tat protein with the transactivation responsive region (TAR) RNA, a 59-base stem-loop structure located at the 5'-end of all HIV mRNAs. Here we report that two TAR RNA-binding peptidomimetics, oligourea and oligocarbamate, inhibit transcriptional activation by Tat protein in human cells with an IC50 of approximately 0.5 and 1 microM, respectively. Peptidomimetics that can target specific RNA structures provide novel molecules that can be used to control cellular processes involving protein-RNA interactions in vivo.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
26
|
|
pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
505-7
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:11229758-Carbamates,
pubmed-meshheading:11229758-Gene Products, tat,
pubmed-meshheading:11229758-HIV-1,
pubmed-meshheading:11229758-HeLa Cells,
pubmed-meshheading:11229758-Humans,
pubmed-meshheading:11229758-Polymers,
pubmed-meshheading:11229758-RNA,
pubmed-meshheading:11229758-Transcriptional Activation,
pubmed-meshheading:11229758-Urea,
pubmed-meshheading:11229758-tat Gene Products, Human Immunodeficiency Virus
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Targeting RNA with peptidomimetic oligomers in human cells.
|
|
pubmed:affiliation |
Department of Pharmacology, Robert Wood Johnson Medical School, and Molecular Biosciences Graduate Program at Rutgers State University, Piscataway, NJ 08854, USA.
|
|
pubmed:publicationType |
Journal Article
|
