|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2001-3-2
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|
pubmed:abstractText |
The design and synthesis of a new type of 5-HT3 ligand with subnanomolar affinity are described. The O-dialkylaminoethyloximinothienopyrrolizine structure was deduced from molecular modeling studies by replacement of an amidine moiety by an oximino one.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
26
|
|
pubmed:volume |
11
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
453-7
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:11229746-Animals,
pubmed-meshheading:11229746-Colon,
pubmed-meshheading:11229746-Dose-Response Relationship, Drug,
pubmed-meshheading:11229746-Guinea Pigs,
pubmed-meshheading:11229746-Models, Molecular,
pubmed-meshheading:11229746-Receptors, Serotonin,
pubmed-meshheading:11229746-Receptors, Serotonin, 5-HT3,
pubmed-meshheading:11229746-Serotonin Antagonists,
pubmed-meshheading:11229746-Serotonin Receptor Agonists,
pubmed-meshheading:11229746-Structure-Activity Relationship
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
First tricyclic oximino derivatives as 5-HT3 ligands.
|
|
pubmed:affiliation |
Centre d'Etudes et de Recherche sur le Médicament de Normandie, Université de Caen, France.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|
