Source:http://linkedlifedata.com/resource/pubmed/id/11224528
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2001-3-26
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| pubmed:databankReference | |
| pubmed:abstractText |
We describe here a newly identified member of the human B7 family, designated B7 homolog 3 (B7-H3), that shares 20-27% amino acid identity with other B7 family members. B7-H3 mRNA is not detectable in peripheral blood mononuclear cells, although it is found in various normal tissues and in several tumor cell lines. Expression of B7-H3 protein, however, can be induced on dendritic cells (DCs) and monocytes by inflammatory cytokines and a combination of phorbol myristate acetate (PMA) + ionomycin. Soluble B7-H3 protein binds a putative counter-receptor on activated T cells that is distinct from CD28, cytotoxic T lymphocyte antigen 4 (CTLA-4), inducible costimulator (ICOS) and PD-1. B7-H3 costimulates proliferation of both CD4+ and CD8+ T cells, enhances the induction of cytotoxic T cells and selectively stimulates interferon gamma (IFN-gamma) production in the presence of T cell receptor signaling. In contrast, inclusion of antisense B7-H3 oligonucleotides decreases the expression of B7-H3 on DCs and inhibits IFN-gamma production by DC-stimulated allogeneic T cells.Thus, we describe a newly identified costimulatory pathway that may participate in the regulation of cell-mediated immune responses.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Isoforms,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic
|
| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
|
| pubmed:issn |
1529-2908
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
2
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
269-74
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:11224528-Amino Acid Sequence,
pubmed-meshheading:11224528-Antigens, CD,
pubmed-meshheading:11224528-Antigens, CD80,
pubmed-meshheading:11224528-B7 Antigens,
pubmed-meshheading:11224528-Cells, Cultured,
pubmed-meshheading:11224528-Cloning, Molecular,
pubmed-meshheading:11224528-Cytokines,
pubmed-meshheading:11224528-Dendritic Cells,
pubmed-meshheading:11224528-Humans,
pubmed-meshheading:11224528-Interferon-gamma,
pubmed-meshheading:11224528-Lymphocyte Activation,
pubmed-meshheading:11224528-Molecular Sequence Data,
pubmed-meshheading:11224528-Protein Isoforms,
pubmed-meshheading:11224528-Receptors, Immunologic,
pubmed-meshheading:11224528-Sequence Homology, Amino Acid,
pubmed-meshheading:11224528-T-Lymphocytes,
pubmed-meshheading:11224528-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:11224528-Transcription, Genetic,
pubmed-meshheading:11224528-Tumor Cells, Cultured
|
| pubmed:year |
2001
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| pubmed:articleTitle |
B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production.
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| pubmed:affiliation |
Department of Immunology, Mayo Graduate and Medical Schools, Mayo Clinic, Rochester, MN 55905, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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