Linked Life Data

11222394

Source:http://linkedlifedata.com/resource/pubmed/id/11222394

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2001-3-6
pubmed:abstractText
Hematopoietic stem cell transplantation (HSCT) is followed by profound immunodeficiency. Thymic function is necessary for de novo generation of T cells after HSCT. Circulating CD45RA(+) naive T-cell levels are predictive of antigen-specific T-cell responses in the absence of graft-versus-host disease (GVHD). These T cells may not represent recent thymic emigrants, since naive T cells may maintain this phenotype if not antigen-activated. To accurately measure thymic output after HSCT and determine the factors that influence thymic function, T-cell receptor excision circles (TRECs) were examined in CD4(+) and CD8(+) cells from a cross-section of patients following HSCT. TREC levels rose weeks after HSCT and could be detected in patients 6 years after HSCT. TREC levels correlated with the frequency of phenotypically naive T cells, indicating that such cells were not expanded progeny of naive T cells present in the donor graft. Chronic GVHD was the most important factor that predicted low TREC levels even years after HSCT. Patients with a history of resolved GVHD had decreased numbers of TREC, compared with those with no GVHD. Because few adults had no history of GVHD, it was not possible to determine whether age alone inversely correlated with TREC levels. Recipients of cord blood grafts had no evidence of decreased TREC induced by immunosuppressive prophylaxis drugs. Compared with unrelated donor grafts, recipients of matched sibling grafts had higher TREC levels. Collectively, these data suggest that thymopoiesis is inhibited by GVHD. Larger studies will be needed to determine the independent contributions of age and preparative regimen to post-transplant thymopoietic capacity.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0006-4971
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
97
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1458-66
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:11222394-Adolescent, pubmed-meshheading:11222394-Adult, pubmed-meshheading:11222394-Age Factors, pubmed-meshheading:11222394-Antigens, CD45, pubmed-meshheading:11222394-CD4-Positive T-Lymphocytes, pubmed-meshheading:11222394-CD8-Positive T-Lymphocytes, pubmed-meshheading:11222394-Child, pubmed-meshheading:11222394-Child, Preschool, pubmed-meshheading:11222394-Cohort Studies, pubmed-meshheading:11222394-Cross-Sectional Studies, pubmed-meshheading:11222394-DNA Repair, pubmed-meshheading:11222394-Fetal Blood, pubmed-meshheading:11222394-Graft vs Host Disease, pubmed-meshheading:11222394-Hematopoietic Stem Cell Transplantation, pubmed-meshheading:11222394-Humans, pubmed-meshheading:11222394-Immunosuppressive Agents, pubmed-meshheading:11222394-Infant, pubmed-meshheading:11222394-Longitudinal Studies, pubmed-meshheading:11222394-Middle Aged, pubmed-meshheading:11222394-Prospective Studies, pubmed-meshheading:11222394-Statistics, Nonparametric, pubmed-meshheading:11222394-Thymus Gland, pubmed-meshheading:11222394-Transplantation, Homologous
pubmed:year
2001
pubmed:articleTitle
Factors affecting thymic function after allogeneic hematopoietic stem cell transplantation.
pubmed:affiliation
Division of Research Immunology/Bone Marrow Transplantation, Childrens Hospital Los Angeles, CA 90027, USA. kweinberg@chla.usc.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't, Multicenter Study