Source:http://linkedlifedata.com/resource/pubmed/id/11222373
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2001-3-6
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| pubmed:abstractText |
Using a variety of differentiation-inducible myeloid cell lines, we previously showed that the zinc-finger transcription factor early growth response gene 1 (Egr-1) is a positive modulator of macrophage differentiation and negatively regulates granulocytic differentiation. In this study, high-efficiency retroviral transduction was used to ectopically express Egr-1 in myeloid-enriched or stem cell-enriched bone marrow cultures to explore its effect on the development of hematopoietic progenitors in vitro and in lethally irradiated mice. It was found that ectopic Egr-1 expression in normal hematopoietic progenitors stimulates development along the macrophage lineage at the expense of development along the granulocyte or erythroid lineages, regardless of the cytokine used. Moreover, Egr-1 accelerated macrophage development by suppressing the proliferative phase of the growth-to-macrophage developmental program. The remarkable ability of Egr-1 to dictate macrophage development at the expense of development along other lineages resulted in failure of Egr-1-infected hematopoietic progenitors to repopulate the bone marrow and spleen, and thereby prevent death, in lethally irradiated mice. These observations further highlight the role Egr-1 plays in monocytic differentiation and growth suppression.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Early Growth Response Protein 1,
http://linkedlifedata.com/resource/pubmed/chemical/Egr1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Immediate-Early Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0006-4971
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
97
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1298-305
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:11222373-Animals,
pubmed-meshheading:11222373-Bone Marrow Cells,
pubmed-meshheading:11222373-Bone Marrow Transplantation,
pubmed-meshheading:11222373-Cell Culture Techniques,
pubmed-meshheading:11222373-Cell Differentiation,
pubmed-meshheading:11222373-Cell Lineage,
pubmed-meshheading:11222373-DNA-Binding Proteins,
pubmed-meshheading:11222373-Early Growth Response Protein 1,
pubmed-meshheading:11222373-Erythrocytes,
pubmed-meshheading:11222373-Female,
pubmed-meshheading:11222373-Granulocytes,
pubmed-meshheading:11222373-Hematopoiesis,
pubmed-meshheading:11222373-Hematopoietic Stem Cells,
pubmed-meshheading:11222373-Immediate-Early Proteins,
pubmed-meshheading:11222373-Macrophages,
pubmed-meshheading:11222373-Mice,
pubmed-meshheading:11222373-Mice, Inbred BALB C,
pubmed-meshheading:11222373-Transcription Factors,
pubmed-meshheading:11222373-Transduction, Genetic,
pubmed-meshheading:11222373-Whole-Body Irradiation
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| pubmed:year |
2001
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| pubmed:articleTitle |
Early growth response gene 1 stimulates development of hematopoietic progenitor cells along the macrophage lineage at the expense of the granulocyte and erythroid lineages.
|
| pubmed:affiliation |
Fels Institute for Cancer Research and Molecular Biology and the Department of Biochemistry, Temple University School of Medicine, Philadelphia, PA 19140, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|