Linked Life Data

1121958

Source:http://linkedlifedata.com/resource/pubmed/id/1121958

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1975-6-20
pubmed:abstractText
Regeneration of olfactory epithelium was studied at the ultrastructural level in two different strains of mice (C57B1/6J and SWR/J) following destructive changes induced by nasal irrigation with 1% aqueous solution of zinc sulfate (ZnSO4). Three epithelial conditions were seen during the first four to 14 days following treatment: a "surface alteration" state characterized by changes at the apical ends of olfactory and columnar supporting cells, a "squamous-metaplastic" state, and a simple-squamous" state. In the latter two conditions, thought to represent regenerative states, cells contained inclusions similar to secretion granules in Bowman's glands. This observation supports earlier suggestions that new epithelial cells originate from these glands. Later regenerative changes consist of differentiation of new sensory cells and columnar supporting cells in an initially disorganized epithelium. This epithelium then changes to a normal, pseudostratified organization. Regeneration of the epithelium begins earlier and proceeds more rapidly in the SWR/J strain than C57B1/6J mice. Possibly, a genetic difference exists between strains. After 72 days the epithelium in both strains had regenerated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0002-9106
pubmed:author
pubmed:issnType
Print
pubmed:volume
142
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
67-89
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Ultrastructural study of mouse olfactory epithelium following destruction by ZnSO4 and its subsequent regeneration.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, Non-P.H.S.