Linked Life Data

1121503

Source:http://linkedlifedata.com/resource/pubmed/id/1121503

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1975-6-21
pubmed:abstractText
The plasma half clearance time (T1/2) of isotope-labeled rabbit hemopexin was 35.5 plus or minus 1.9 hr in rabbits. After intra-and extra-vascular equilibration of 125I-hemopexin and 131I-albumin, injection of either hematin, hemoglobin or methemoglobin (12.5 mg of heme/kg body wt) resulted in the rapid removal of 60-80% of circulating hemopexin (T1/2 = 7.2 plus or minus 0.6 hr) but did not affect albumin catabolism. After selective photo-inactivation of hemopexin, the T1/2 of this hemopexin was comparable to that of the native molecule. However, its plasma disappearance curve was not appreciably affected by administration of hematin. These findings demonstrate that hemopexin is cleared and catabolized at an enhanced rate during states of plasma heme load, and that modification of critical histidine residues of hemopexin eliminates its biological function in plasma heme disposal.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0037-9727
pubmed:author
pubmed:issnType
Print
pubmed:volume
148
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
519-22
pubmed:dateRevised
2007-11-2
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Effect of hemoglobin and hematin on plasma clearance of hemopexin, photo-inactivated hemopexin and albumin (38575).
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.