rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2001-2-9
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pubmed:abstractText |
New anti-Helicobacter pylori (H. pylori) agents endowed with H2-antagonists properties were obtained by combining the lamtidine derived pharmacophoric group with the antibiotic calvatic acid. All the compounds were tested for their irreversible H2-antagonist properties and for their ability to inhibit 20 H. pylori strains, two of them metronidazole resistant. The most active derivative (compound 4) displayed antimicrobial activity similar to metronidazole.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Bacterial Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Benzoates,
http://linkedlifedata.com/resource/pubmed/chemical/Histamine,
http://linkedlifedata.com/resource/pubmed/chemical/Histamine H2 Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Metronidazole,
http://linkedlifedata.com/resource/pubmed/chemical/Nitriles,
http://linkedlifedata.com/resource/pubmed/chemical/Piperidines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Histamine H2,
http://linkedlifedata.com/resource/pubmed/chemical/Triazoles,
http://linkedlifedata.com/resource/pubmed/chemical/calvatic acid,
http://linkedlifedata.com/resource/pubmed/chemical/lamtidine
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0960-894X
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
403-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11212121-Animals,
pubmed-meshheading:11212121-Anti-Bacterial Agents,
pubmed-meshheading:11212121-Benzoates,
pubmed-meshheading:11212121-Binding, Competitive,
pubmed-meshheading:11212121-Combinatorial Chemistry Techniques,
pubmed-meshheading:11212121-Dose-Response Relationship, Drug,
pubmed-meshheading:11212121-Drug Resistance,
pubmed-meshheading:11212121-Guinea Pigs,
pubmed-meshheading:11212121-Heart Atria,
pubmed-meshheading:11212121-Helicobacter pylori,
pubmed-meshheading:11212121-Histamine,
pubmed-meshheading:11212121-Histamine H2 Antagonists,
pubmed-meshheading:11212121-Metronidazole,
pubmed-meshheading:11212121-Microbial Sensitivity Tests,
pubmed-meshheading:11212121-Nitriles,
pubmed-meshheading:11212121-Piperidines,
pubmed-meshheading:11212121-Receptors, Histamine H2,
pubmed-meshheading:11212121-Structure-Activity Relationship,
pubmed-meshheading:11212121-Triazoles
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pubmed:year |
2001
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pubmed:articleTitle |
Anti-Helicobacter pylori agents endowed with H2-antagonist properties.
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pubmed:affiliation |
Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche, Università degli Studi del Piemonte Orientale, Novara, Italy.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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