rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2001-2-9
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pubmed:abstractText |
Novel rigidified (R)-aporphine derivatives were synthesized from (R)-1,11-carbonylaporphine by ring expansion reactions. The structures of the novel analogues were assigned by NMR spectroscopy and X-ray crystallography. The compounds showed moderate affinities and selectivities at serotonin S-HT1A and 5-HT7 and dopamine D2A receptors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aporphines,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin, 5-HT1,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Receptor Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/aporphine,
http://linkedlifedata.com/resource/pubmed/chemical/serotonin 7 receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0960-894X
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
367-70
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:11212112-Animals,
pubmed-meshheading:11212112-Aporphines,
pubmed-meshheading:11212112-Combinatorial Chemistry Techniques,
pubmed-meshheading:11212112-Dopamine Agonists,
pubmed-meshheading:11212112-Hippocampus,
pubmed-meshheading:11212112-Humans,
pubmed-meshheading:11212112-Molecular Conformation,
pubmed-meshheading:11212112-Protein Binding,
pubmed-meshheading:11212112-Receptors, Dopamine D2,
pubmed-meshheading:11212112-Receptors, Serotonin,
pubmed-meshheading:11212112-Receptors, Serotonin, 5-HT1,
pubmed-meshheading:11212112-Serotonin Receptor Agonists,
pubmed-meshheading:11212112-Stereoisomerism,
pubmed-meshheading:11212112-Structure-Activity Relationship
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pubmed:year |
2001
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pubmed:articleTitle |
Serotonergic and dopaminergic activities of rigidified (R)-aporphine derivatives.
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pubmed:affiliation |
Organic Pharmaceutical Chemistry, Uppsala University, Uppsala Biomedical Center, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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