Linked Life Data

1120957

Source:http://linkedlifedata.com/resource/pubmed/id/1120957

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1975-6-26
pubmed:abstractText
Chronic administration of ethanol to rats leads to an increase in the rate of ethanol metabolism in vivo and in vitro. In vitro studies in liver slices showed that ouabain, an inhibitor of the Na++K+-activated adenosine triphosphatase, can completely block the extra ethanol metabolism in the livers of the treated animals only in the presence of ouabain. Administration of thyroxine led to an increase in the rate of ethanol metabolism when measured both in vitro and in vivo. This effect was biphasic; an activation occurred only with low doses of thyroxine but disappeared after administration of larger doses. Alcohol dehydrogenase activity in the liver of the animals treated with large doses of thyroxine was found to be significantly reduced. With the doses used (50-1000 mug/kg), thyroxine also increased the rate of oxygen consumption as measured in liver slices. However, a biphasic effect did not occur; a near maximum activation on the rate of oxygen consumption occurred with low doses of thyroxine (100 mug/kg). Oxygen consumption was also found to be increased in the liver of animals chronically treated with ethanol. A maximal effect was produced after 18 to 21 days of treatment. For both ethanol and thyroxine-treated animals, an increased rate of oxygen consumption occurred with a concomitant loss of dinitrophenol effect. Mitochondrial alpha-glycerophosphate oxidase was found to be increased in the liver of animals treated with ethanol or with thyroxine. In these two groups, this enzymatic activity appeared to be less affected by the treatment than the dinitrophenol-activated respiration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-3565
pubmed:author
pubmed:issnType
Print
pubmed:volume
192
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
565-74
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Effects of chronic ethanol treatment and thyroxine administration on ethanol metabolism and liver oxidative capacity.
pubmed:publicationType
Journal Article, In Vitro