|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2002-7-23
|
|
pubmed:abstractText |
We have studied the in vivo effect of the selective agonist for group II metabotropic glutamate receptors (2S, 2'R, 3'R)-2-(2'3'-dicarboxycyclopropyl)glycine (DCG-IV) against MPP+-induced toxicity on rat striatal dopaminergic nerve terminals by using both microdialysis and immunohistochemical techniques. Perfusion of 1 mM DCG-IV during 1 h protected dopaminergic nerve terminals against the degeneration induced by a 15-minute perfusion of 1 mM MPP+. In addition, the microglial cell population was markedly activated 24 h after DCG-IV perfusion. The astroglial cell population was only markedly activated around the microdialysis probe. This protective effect seems to be dependent on protein synthesis since 1 mM cycloheximide, an inhibitor of protein synthesis, abolished the neuroprotective effect of 1 mM DCG-IV against MPP+ toxicity. Perfusion of DCG-IV induced an upregulation of striatal brain-derived neurotrophic factor (BDNF) mRNA expressing cells which were confined precisely around the microdialysis probe. Taken together, our results suggest that the induction and release of brain-derived neurotrophic factor (BDNF) by activated glial cells induced by DCG-IV perfusion may account for its protective action against MPP+-induced dopaminergic terminal degeneration.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-Methyl-4-phenyl-1,2,3,6-tetrahydro...,
http://linkedlifedata.com/resource/pubmed/chemical/2-(2,3-dicarboxycyclopropyl)glycine,
http://linkedlifedata.com/resource/pubmed/chemical/Benzoates,
http://linkedlifedata.com/resource/pubmed/chemical/Brain-Derived Neurotrophic Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclopropanes,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Glycine,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Synthesis Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Metabotropic Glutamate,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-methyl-4-carboxyphenylglycine
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0022-3042
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
76
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
351-60
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:11208898-1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine,
pubmed-meshheading:11208898-Animals,
pubmed-meshheading:11208898-Benzoates,
pubmed-meshheading:11208898-Brain-Derived Neurotrophic Factor,
pubmed-meshheading:11208898-Corpus Striatum,
pubmed-meshheading:11208898-Cyclopropanes,
pubmed-meshheading:11208898-Disease Models, Animal,
pubmed-meshheading:11208898-Dopamine,
pubmed-meshheading:11208898-Dopamine Agents,
pubmed-meshheading:11208898-Excitatory Amino Acid Agonists,
pubmed-meshheading:11208898-Excitatory Amino Acid Antagonists,
pubmed-meshheading:11208898-Glycine,
pubmed-meshheading:11208898-Immunohistochemistry,
pubmed-meshheading:11208898-In Situ Hybridization,
pubmed-meshheading:11208898-MPTP Poisoning,
pubmed-meshheading:11208898-Male,
pubmed-meshheading:11208898-Microdialysis,
pubmed-meshheading:11208898-Microglia,
pubmed-meshheading:11208898-Neurons,
pubmed-meshheading:11208898-Presynaptic Terminals,
pubmed-meshheading:11208898-Protein Synthesis Inhibitors,
pubmed-meshheading:11208898-RNA, Messenger,
pubmed-meshheading:11208898-Rats,
pubmed-meshheading:11208898-Rats, Wistar,
pubmed-meshheading:11208898-Receptors, Metabotropic Glutamate
|
|
pubmed:year |
2001
|
|
pubmed:articleTitle |
Group II metabotropic glutamate receptor activation protects striatal dopaminergic nerve terminals against MPP+-induced neurotoxicity along with brain-derived neurotrophic factor induction.
|
|
pubmed:affiliation |
Departamento de Bioquímica, Bromatología, Toxicología y Medicina Legal, Facultad de Farmacia, Universidad de Sevilla, Spain.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
