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rdf:type |
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lifeskim:mentions |
|
|
pubmed:issue |
2
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pubmed:dateCreated |
2001-3-6
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|
pubmed:abstractText |
Mutations in the K-ras gene are frequent in human cancer. ras activation in primary cells results in a cellular senescence phenotype that is precluded by inactivation of p16. At the clinical level, this may imply a differential behavior for tumors with alternative or cooperative activation of K-ras function and impairment of p16 pathways.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0732-183X
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
299-304
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11208819-Adenocarcinoma,
pubmed-meshheading:11208819-Adult,
pubmed-meshheading:11208819-Aged,
pubmed-meshheading:11208819-Aged, 80 and over,
pubmed-meshheading:11208819-Chromosome Aberrations,
pubmed-meshheading:11208819-Colorectal Neoplasms,
pubmed-meshheading:11208819-DNA Methylation,
pubmed-meshheading:11208819-DNA Mutational Analysis,
pubmed-meshheading:11208819-Female,
pubmed-meshheading:11208819-Follow-Up Studies,
pubmed-meshheading:11208819-Genes, p16,
pubmed-meshheading:11208819-Genes, p53,
pubmed-meshheading:11208819-Genes, ras,
pubmed-meshheading:11208819-Humans,
pubmed-meshheading:11208819-Male,
pubmed-meshheading:11208819-Middle Aged,
pubmed-meshheading:11208819-Multivariate Analysis,
pubmed-meshheading:11208819-Mutation,
pubmed-meshheading:11208819-Prognosis,
pubmed-meshheading:11208819-Proportional Hazards Models,
pubmed-meshheading:11208819-Prospective Studies,
pubmed-meshheading:11208819-Proteins,
pubmed-meshheading:11208819-Survival Analysis,
pubmed-meshheading:11208819-Tumor Suppressor Protein p14ARF
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pubmed:year |
2001
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pubmed:articleTitle |
K-ras and p16 aberrations confer poor prognosis in human colorectal cancer.
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pubmed:affiliation |
Johns Hopkins Oncology Center, Baltimore, MD, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Evaluation Studies
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