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pubmed-article:11208716pubmed:abstractTextPurified intestinal epithelial cells die of detachment-induced apoptosis due to loss of cell anchorage during isolation. Anchorage-dependent cells form focal adhesions, sites of enhanced cell-matrix attachment that confer survival signals. Focal adhesion kinase (FAK), a component of the focal adhesion signaling complex, transduces these antiapoptotic signals. In this report, the molecular events leading to cleavage of FAK by caspases during apoptosis and its functional implications are defined.lld:pubmed
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pubmed-article:11208716pubmed:articleTitleHierarchical cleavage of focal adhesion kinase by caspases alters signal transduction during apoptosis of intestinal epithelial cells.lld:pubmed
pubmed-article:11208716pubmed:affiliationDepartment of Medicine I, University of Regensburg, Germany.lld:pubmed
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pubmed-article:11208716pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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