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rdf:type |
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lifeskim:mentions |
umls-concept:C0007102,
umls-concept:C0017262,
umls-concept:C0054312,
umls-concept:C0086418,
umls-concept:C0162638,
umls-concept:C0185117,
umls-concept:C0205263,
umls-concept:C0248813,
umls-concept:C0334227,
umls-concept:C1704259,
umls-concept:C1705987,
umls-concept:C1879547,
umls-concept:C1948023,
umls-concept:C2911684
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|
pubmed:issue |
1
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|
pubmed:dateCreated |
2001-3-6
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|
pubmed:abstractText |
The colonic epithelial cells near the top of the crypt have been shown to undergo apoptosis. Because butyric acid (BA) is the major short-chain fatty acid produced by fermentation of dietary fiber in the large bowel, it may be an important regulator of apoptosis in colorectal cancer. We investigated which signaling pathway is triggered by BA to undergo apoptosis in human colorectal cancer cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0016-5085
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
120
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
71-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11208715-Apoptosis,
pubmed-meshheading:11208715-Butyric Acid,
pubmed-meshheading:11208715-Colorectal Neoplasms,
pubmed-meshheading:11208715-DNA Fragmentation,
pubmed-meshheading:11208715-Gene Expression Regulation,
pubmed-meshheading:11208715-Histamine Antagonists,
pubmed-meshheading:11208715-Humans,
pubmed-meshheading:11208715-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:11208715-Mitogen-Activated Protein Kinases,
pubmed-meshheading:11208715-Mutagenesis,
pubmed-meshheading:11208715-Promoter Regions, Genetic,
pubmed-meshheading:11208715-Proto-Oncogene Proteins,
pubmed-meshheading:11208715-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:11208715-Transcription Factor AP-1,
pubmed-meshheading:11208715-Transcriptional Activation,
pubmed-meshheading:11208715-Tumor Cells, Cultured,
pubmed-meshheading:11208715-bcl-2-Associated X Protein
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pubmed:year |
2001
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pubmed:articleTitle |
Butyric acid induces apoptosis by up-regulating Bax expression via stimulation of the c-Jun N-terminal kinase/activation protein-1 pathway in human colon cancer cells.
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pubmed:affiliation |
University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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