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rdf:type |
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lifeskim:mentions |
umls-concept:C0007585,
umls-concept:C0016055,
umls-concept:C0030685,
umls-concept:C0039062,
umls-concept:C0043342,
umls-concept:C0132298,
umls-concept:C0205359,
umls-concept:C0282116,
umls-concept:C0331858,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1704640,
umls-concept:C1706515,
umls-concept:C1707723,
umls-concept:C1963578,
umls-concept:C1979768,
umls-concept:C1998811
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pubmed:issue |
2
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pubmed:dateCreated |
2001-6-26
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pubmed:abstractText |
Integrins mediate cell-extracellular matrix connection and are particularly important during neuronal development. We here investigated the regulation of fibronectin (FN) matrix and neurotrophins on the embryonic synaptic transmission. Spontaneous synaptic currents (SSCs) were recorded from innervated myocytes of 1-day-old Xenopus cultures by whole-cell recordings. The SSC increasing action of alpha,beta-methylene adenosine triphosphate was enhanced in neurons grown on FN substratum, which was further potentiated by chronic treatment with brain-derived neurotrophic factor (BDNF). The SSC increasing action of thapsigargin, carbonyl cyanide m-chlorophenylhydrazone and N-methyl-D-aspartate was also markedly potentiated in neurons grown on FN-coated glass coverslips and chronically treated with BDNF. FN matrix or BDNF alone only exerts slight potentiation on the SSC increasing action of these three drugs. Our results suggest that FN matrix can collaborate with neurotrophin in regulating synaptic transmission at developing motoneurons, which may play an important role in the maturation of embryonic neuromuscular junction.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetylcholine,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Brain-Derived Neurotrophic Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Carbonyl Cyanide m-Chlorophenyl...,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Fibronectins,
http://linkedlifedata.com/resource/pubmed/chemical/Integrins,
http://linkedlifedata.com/resource/pubmed/chemical/N-Methylaspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Growth Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Neurotransmitter Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Neurotrophin 3,
http://linkedlifedata.com/resource/pubmed/chemical/Thapsigargin,
http://linkedlifedata.com/resource/pubmed/chemical/Uncoupling Agents,
http://linkedlifedata.com/resource/pubmed/chemical/alpha,beta-methyleneadenosine...
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
300
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
115-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11207388-Acetylcholine,
pubmed-meshheading:11207388-Adenosine Triphosphate,
pubmed-meshheading:11207388-Animals,
pubmed-meshheading:11207388-Brain-Derived Neurotrophic Factor,
pubmed-meshheading:11207388-Calcium,
pubmed-meshheading:11207388-Carbonyl Cyanide m-Chlorophenyl Hydrazone,
pubmed-meshheading:11207388-Cells, Cultured,
pubmed-meshheading:11207388-Enzyme Inhibitors,
pubmed-meshheading:11207388-Extracellular Matrix,
pubmed-meshheading:11207388-Fibronectins,
pubmed-meshheading:11207388-Integrins,
pubmed-meshheading:11207388-Membrane Potentials,
pubmed-meshheading:11207388-N-Methylaspartate,
pubmed-meshheading:11207388-Nerve Growth Factors,
pubmed-meshheading:11207388-Neuromuscular Junction,
pubmed-meshheading:11207388-Neurotransmitter Agents,
pubmed-meshheading:11207388-Neurotrophin 3,
pubmed-meshheading:11207388-Synaptic Transmission,
pubmed-meshheading:11207388-Thapsigargin,
pubmed-meshheading:11207388-Uncoupling Agents,
pubmed-meshheading:11207388-Xenopus laevis
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pubmed:year |
2001
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pubmed:articleTitle |
Collaboration of fibronectin matrix and neurotrophin in regulating spontaneous transmitter release at developing neuromuscular synapses in Xenopus cell cultures.
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pubmed:affiliation |
Pharmacological Institute, College of Medicine, National Taiwan University, Taipei. wenmei@ccms.ntu.edu.tw
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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