Source:http://linkedlifedata.com/resource/pubmed/id/11207315
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2001-3-14
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| pubmed:abstractText |
Occupational exposure to small molecules, such as metals, is frequently associated with hypersensitivity reactions. Chronic beryllium (Be) disease (CBD) is a multisystem granulomatous disease that primarily affects the lung, and occurs in approximately 3% of individuals exposed to this element. Immunogenetic studies have demonstrated a strong association between CBD and possession of alleles of HLA-DP containing glutamic acid (Glu) at position 69 in the HLA-DP beta-chain. T cell clones were raised from three patients with CBD in whom exposure occurred 10 and 30 years previously. Of 25 Be-specific clones that were obtained, all were restricted by HLA-DP alleles with Glu at DP beta69. Furthermore, the proliferative responses of the clones were absolutely dependent upon DP beta Glu(69) in that a single amino acid substitution at this position abolished the response. As befits a disease whose pathogenesis involves a delayed type hypersensitivity response, the large majority of Be-specific clones secreted IFN-gamma (Th1) and little or no IL-4 (Th2) cytokines. This study provides insights into the molecular basis of DP2-associated susceptibility to CBD.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Beryllium,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, T-Lymphocyte,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DP Antigens
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0022-1767
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
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| pubmed:volume |
166
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
3549-55
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11207315-Alleles,
pubmed-meshheading:11207315-Amino Acid Substitution,
pubmed-meshheading:11207315-Animals,
pubmed-meshheading:11207315-Berylliosis,
pubmed-meshheading:11207315-Beryllium,
pubmed-meshheading:11207315-Cell Culture Techniques,
pubmed-meshheading:11207315-Cell Line, Transformed,
pubmed-meshheading:11207315-Chronic Disease,
pubmed-meshheading:11207315-Clone Cells,
pubmed-meshheading:11207315-Cytokines,
pubmed-meshheading:11207315-Epitopes, T-Lymphocyte,
pubmed-meshheading:11207315-Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor,
pubmed-meshheading:11207315-Gene Rearrangement, beta-Chain T-Cell Antigen Receptor,
pubmed-meshheading:11207315-Genetic Predisposition to Disease,
pubmed-meshheading:11207315-Glutamic Acid,
pubmed-meshheading:11207315-HLA-DP Antigens,
pubmed-meshheading:11207315-Humans,
pubmed-meshheading:11207315-Male,
pubmed-meshheading:11207315-Mice,
pubmed-meshheading:11207315-T-Lymphocyte Subsets,
pubmed-meshheading:11207315-Th1 Cells,
pubmed-meshheading:11207315-Transfection
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| pubmed:year |
2001
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| pubmed:articleTitle |
HLA-DP allele-specific T cell responses to beryllium account for DP-associated susceptibility to chronic beryllium disease.
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| pubmed:affiliation |
Department of Immunology, Imperial College School of Medicine, Hammersmith Hospital, London, United Kingdom. g.lombardi@ic.ac.uk
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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