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rdf:type |
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lifeskim:mentions |
umls-concept:C0004561,
umls-concept:C0011306,
umls-concept:C0017262,
umls-concept:C0282491,
umls-concept:C0439640,
umls-concept:C0541270,
umls-concept:C1171362,
umls-concept:C1332681,
umls-concept:C1512987,
umls-concept:C1515670,
umls-concept:C1706483
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pubmed:issue |
5
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pubmed:dateCreated |
2001-3-14
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pubmed:abstractText |
DC-CK1 (CCL18) is a dendritic cell (DC)-specific chemokine expressed in both T and B cell areas of secondary lymphoid organs that preferentially attracts CD45RA(+) T cells. In this study, we further explored the nature of DC-CK1 expressing cells in germinal centers (GCs) of secondary lymphoid organs using a newly developed anti-DC-CK1 mAb. Immunohistochemical analysis demonstrated a remarkable difference in the number of DC-CK1 expressing cells in adjacent GCs within one tonsil, implicating that the expression of DC-CK1 in GCs depends on the activation and/or progression stage of the GC reaction. Using immunohistology and RNA analysis, we demonstrated that GCDC are the source of DC-CK1 production in the GCs. Considering the recently described function of GCDC in (naive) B cell proliferation, isotype switching and Ab production, we investigated the ability of DC-CK1 to attract B lymphocytes. Here we demonstrate that DC-CK1 is a pertussis toxin-dependent chemoattractant for B lymphocytes with a preference in attracting mantle zone (CD38(-)) B cells. The findings that GCDC produce DC-CK1 and attract mantle zone B cells support a key role for GCDC in the development of GCs and memory B cell formation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ADP-ribosyl Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD38,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/CCL18 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CD38 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CC,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/NAD Nucleosidase
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
166
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3284-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11207283-ADP-ribosyl Cyclase,
pubmed-meshheading:11207283-Antigens, CD,
pubmed-meshheading:11207283-Antigens, CD38,
pubmed-meshheading:11207283-Antigens, Differentiation,
pubmed-meshheading:11207283-B-Lymphocyte Subsets,
pubmed-meshheading:11207283-Cell Communication,
pubmed-meshheading:11207283-Chemokines, CC,
pubmed-meshheading:11207283-Chemotaxis, Leukocyte,
pubmed-meshheading:11207283-Child,
pubmed-meshheading:11207283-Dendritic Cells,
pubmed-meshheading:11207283-Germinal Center,
pubmed-meshheading:11207283-Humans,
pubmed-meshheading:11207283-Lymph Nodes,
pubmed-meshheading:11207283-Membrane Glycoproteins,
pubmed-meshheading:11207283-NAD+ Nucleosidase,
pubmed-meshheading:11207283-Palatine Tonsil,
pubmed-meshheading:11207283-Spleen,
pubmed-meshheading:11207283-T-Lymphocytes
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pubmed:year |
2001
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pubmed:articleTitle |
The dendritic cell-specific CC-chemokine DC-CK1 is expressed by germinal center dendritic cells and attracts CD38-negative mantle zone B lymphocytes.
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pubmed:affiliation |
Department of Tumor Immunology, University Medical Center, Nijmegen, The Netherlands.
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pubmed:publicationType |
Journal Article
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