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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2001-3-14
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pubmed:abstractText |
A lymphoid-committed progenitor population was isolated from mouse bone marrow based on the cell surface phenotype Thy-1.1(neg)Sca-1(pos)c-Kit(low)Lin(neg). These cells were CD43(pos)CD24(pos) on isolation and proliferated in response to the cytokine combination of steel factor, IL-7, and Flt3 ligand. Lymphoid-committed progenitors could be segregated into more primitive and more differentiated subsets based on expression of AA4.1. The more differentiated subset generated only B lymphoid cells in 92% of total colonies assayed, lacked T lineage potential, and expressed Pax5. These studies have therefore defined and isolated a B lymphoid-committed progenitor population at a developmental stage corresponding to the initial expression of CD45R.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD44,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Thy-1,
http://linkedlifedata.com/resource/pubmed/chemical/C1qbp protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-kit,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Complement,
http://linkedlifedata.com/resource/pubmed/chemical/complement 1q receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
166
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3042-51
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11207254-Aging,
pubmed-meshheading:11207254-Animals,
pubmed-meshheading:11207254-Antigens, CD44,
pubmed-meshheading:11207254-Antigens, Differentiation, B-Lymphocyte,
pubmed-meshheading:11207254-Antigens, Thy-1,
pubmed-meshheading:11207254-B-Lymphocyte Subsets,
pubmed-meshheading:11207254-Bone Marrow Cells,
pubmed-meshheading:11207254-Cell Differentiation,
pubmed-meshheading:11207254-Cell Lineage,
pubmed-meshheading:11207254-Cell Separation,
pubmed-meshheading:11207254-Cells, Cultured,
pubmed-meshheading:11207254-Gene Expression Regulation, Developmental,
pubmed-meshheading:11207254-Immunophenotyping,
pubmed-meshheading:11207254-Membrane Glycoproteins,
pubmed-meshheading:11207254-Mice,
pubmed-meshheading:11207254-Mice, Inbred AKR,
pubmed-meshheading:11207254-Mice, Inbred C57BL,
pubmed-meshheading:11207254-Myeloid Cells,
pubmed-meshheading:11207254-Proto-Oncogene Proteins c-kit,
pubmed-meshheading:11207254-Receptors, Complement,
pubmed-meshheading:11207254-Stem Cells
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pubmed:year |
2001
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pubmed:articleTitle |
Phenotypic distinction and functional characterization of pro-B cells in adult mouse bone marrow.
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pubmed:affiliation |
Department of Human Genetics, University of Utah, Salt Lake City, UT 84132, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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