11206467

Source:http://linkedlifedata.com/resource/pubmed/id/11206467

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0268563, umls-concept:C1513016, umls-concept:C1880355
pubmed:issue	2
pubmed:dateCreated	2001-2-5
pubmed:abstractText	A novel series of anthranilic acid-based inhibitors of MMP-1, MMP-9, and MMP-13 was prepared and evaluated both in vitro and in vivo. The most potent compound, 6e, has in vivo activity in a rat sponge-wrapped cartilage model.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Anthranilic Acids, http://linkedlifedata.com/resource/pubmed/chemical/Collagenases, http://linkedlifedata.com/resource/pubmed/chemical/Hydroxamic Acids, http://linkedlifedata.com/resource/pubmed/chemical/MMP13 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 1, http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 13, http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 9, http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinases, http://linkedlifedata.com/resource/pubmed/chemical/Mmp13 protein, rat, http://linkedlifedata.com/resource/pubmed/chemical/Protease Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides, http://linkedlifedata.com/resource/pubmed/chemical/anthranilic acid
pubmed:status	MEDLINE
pubmed:month	Jan
pubmed:issn	0960-894X
pubmed:author	pubmed-author:CowlingRR, pubmed-author:DiJosephJ FJF, pubmed-author:JiaJJ, pubmed-author:KillarL MLM, pubmed-author:LevinJ IJI, pubmed-author:MeoGG, pubmed-author:MoyF JFJ, pubmed-author:PowersRR, pubmed-author:RothC ECE, pubmed-author:SharrM AMA, pubmed-author:SkotnickiJ SJS, pubmed-author:SundBB, pubmed-author:WalterTT
pubmed:issnType	Print
pubmed:day	22
pubmed:volume	11
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	235-8
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:11206467-Animals, pubmed-meshheading:11206467-Anthranilic Acids, pubmed-meshheading:11206467-Collagenases, pubmed-meshheading:11206467-Combinatorial Chemistry Techniques, pubmed-meshheading:11206467-Humans, pubmed-meshheading:11206467-Hydroxamic Acids, pubmed-meshheading:11206467-Inhibitory Concentration 50, pubmed-meshheading:11206467-Matrix Metalloproteinase 1, pubmed-meshheading:11206467-Matrix Metalloproteinase 13, pubmed-meshheading:11206467-Matrix Metalloproteinase 9, pubmed-meshheading:11206467-Matrix Metalloproteinases, pubmed-meshheading:11206467-Protease Inhibitors, pubmed-meshheading:11206467-Structure-Activity Relationship, pubmed-meshheading:11206467-Sulfonamides
pubmed:year	2001
pubmed:articleTitle	The discovery of anthranilic acid-based MMP inhibitors. Part 1: SAR of the 3-position.
pubmed:affiliation	Wyeth-Ayerst Research, Pearl River, NY 10965, USA. levinji@war.wyeth.com
pubmed:publicationType	Journal Article