Source:http://linkedlifedata.com/resource/pubmed/id/11206451
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2001-2-5
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pubmed:abstractText |
Two deoxy-analogues of the anticancer/antiviral agent pancratistatin containing functionality complementary to the minimum structural pharmacophore were synthesized and subjected to anticancer screening. One of the analogues exhibited selective inhibition of certain tumor cell lines but was significantly less potent than the natural products. The minimum structural pharmacophore has now been refined from eight to three possible structures.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0960-894X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
169-72
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11206451-Amaryllidaceae Alkaloids,
pubmed-meshheading:11206451-Animals,
pubmed-meshheading:11206451-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:11206451-Cell Division,
pubmed-meshheading:11206451-Drug Screening Assays, Antitumor,
pubmed-meshheading:11206451-Humans,
pubmed-meshheading:11206451-Inhibitory Concentration 50,
pubmed-meshheading:11206451-Isoquinolines,
pubmed-meshheading:11206451-Mice,
pubmed-meshheading:11206451-Models, Molecular,
pubmed-meshheading:11206451-Structure-Activity Relationship,
pubmed-meshheading:11206451-Tumor Cells, Cultured
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pubmed:year |
2001
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pubmed:articleTitle |
Studies directed towards the refinement of the pancratistatin cytotoxic pharmacophore.
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pubmed:affiliation |
Institute of Molecular Catalysis, Department of Chemistry, Brock University, St. Catharines, Ontario, Canada. jmcnulty@chemiris.labs.brocku.ca
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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