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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2001-2-1
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pubmed:abstractText |
The absence or the presence of low levels of the Coxsackievirus and adenovirus receptor (CAR) on several tumor types might limit the efficacy of recently proposed tumor-specific or conditionally replicative adenoviruses (CRAds). To address this issue, we used a genetic modification of the fiber knob in the context of an E1A-defective CRAd to allow CAR-independent target cell infection as a means to enhance oncolytic potency. Such infectivity-enhanced CRAd showed higher replication, more efficient infection, and lysis of tumor cells in vitro. Of note, the improved antitumor effect of the fiber-modified CRAd could be demonstrated in vivo. We conclude that the combination of genomic modification to achieve tumor-selective replication and capsid modification to enhance infectivity yields more potent oncolytic adenoviruses for use in cancer treatment.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
120-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11205899-Adenoviridae,
pubmed-meshheading:11205899-Adenovirus E1A Proteins,
pubmed-meshheading:11205899-Animals,
pubmed-meshheading:11205899-Cell Division,
pubmed-meshheading:11205899-Female,
pubmed-meshheading:11205899-Formazans,
pubmed-meshheading:11205899-Genetic Vectors,
pubmed-meshheading:11205899-Humans,
pubmed-meshheading:11205899-Immunologic Tests,
pubmed-meshheading:11205899-Luciferases,
pubmed-meshheading:11205899-Lung Neoplasms,
pubmed-meshheading:11205899-Male,
pubmed-meshheading:11205899-Mice,
pubmed-meshheading:11205899-Mice, Nude,
pubmed-meshheading:11205899-Oligopeptides,
pubmed-meshheading:11205899-Prostatic Neoplasms,
pubmed-meshheading:11205899-Retinoblastoma Protein,
pubmed-meshheading:11205899-Time Factors,
pubmed-meshheading:11205899-Transplantation, Heterologous,
pubmed-meshheading:11205899-Tumor Cells, Cultured,
pubmed-meshheading:11205899-Virus Replication,
pubmed-meshheading:11205899-Viruses
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pubmed:year |
2001
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pubmed:articleTitle |
A conditionally replicative adenovirus with enhanced infectivity shows improved oncolytic potency.
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pubmed:affiliation |
Gene Therapy Center, University of Alabama at Birmingham, 35294-3300, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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