Source:http://linkedlifedata.com/resource/pubmed/id/11205358
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4 Suppl 2
|
| pubmed:dateCreated |
2001-2-2
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| pubmed:abstractText |
Two hundred and twenty-four patients at their first diagnosis of multiple sclerosis (MS) were prospectively followed for a mean period of 9.78 years. We considered as endpoints the time to reach non-reversible disability levels corresponding to EDSS scores of 4.0 and 6.0, and the beginning of a secondary progressive phase in the relapsing-remitting subgroup of patients. An initially progressive course and higher basal EDSS scores proved to be the best predictors of unfavorable prognosis. A greater number of functional systems involved at onset as well as higher residual deficits in pyramidal, visual, sphincteric and cerebellar systems were other factors predictive of a poor outcome, whereas sensory system involvement turned out to be favorable. A longer first inter-attack interval was associated with a better prognosis. However, overall number of relapses in the first two years of the disease was of no prognostic value. The presence of oligoclonal banding in the cerebrospinal fluid and a cerebral MRI exam strongly suggestive or suggestive of MS in the early phases of the disease were associated with a higher probability of a worse outcome.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
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| pubmed:issn |
1590-1874
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
21
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
S831-8
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:11205358-Adolescent,
pubmed-meshheading:11205358-Adult,
pubmed-meshheading:11205358-Age of Onset,
pubmed-meshheading:11205358-Brain,
pubmed-meshheading:11205358-Disability Evaluation,
pubmed-meshheading:11205358-Disease Progression,
pubmed-meshheading:11205358-Female,
pubmed-meshheading:11205358-Humans,
pubmed-meshheading:11205358-Male,
pubmed-meshheading:11205358-Middle Aged,
pubmed-meshheading:11205358-Multiple Sclerosis,
pubmed-meshheading:11205358-Predictive Value of Tests,
pubmed-meshheading:11205358-Prognosis,
pubmed-meshheading:11205358-Prospective Studies,
pubmed-meshheading:11205358-Recurrence,
pubmed-meshheading:11205358-Regression Analysis,
pubmed-meshheading:11205358-Risk Factors,
pubmed-meshheading:11205358-Sex Factors
|
| pubmed:year |
2000
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| pubmed:articleTitle |
A prospective study on the prognosis of multiple sclerosis.
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| pubmed:affiliation |
Department of Neurology, University of Florence, Italy.
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| pubmed:publicationType |
Journal Article
|