Linked Life Data

1120478

Source:http://linkedlifedata.com/resource/pubmed/id/1120478

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1975-6-26
pubmed:abstractText
Seminiferous tubules isolated from normal adult rats converted (14C) testosterone to (14C) androstanediol and (14C) androstenedione as the major metabolites; (14C) dihydrotestosterone and (14C) androsterone were produced in lesser amounts. Tubules from immature rats (26-28 days of age) converted a higher proportion of (14C) testosterone to 5alpha-reduced products than did tubules from adult rats. Spermatocyte-enriched preparations contain 5alpha-reductase. The lower level of 5alpha-reductase activity in spermatid-spermatocyte preparations indicates that this enzyme is low or absent in spermatids. Sertoli cell-enriched preparations contain 5 alpha-reductase and a high level of 3alpha-hydroxysteroid dehydrogenase. The results show that spermatocytes and Sertoli cells have the capacity to metabolise (14C) testosterone to 5alpha-reduced products; dihydrotesterone is the major product formed by spermatocytes, whereas in Sertoli cells further metabolism to 5alpha-androstane-3alpha, 17beta-diol occurs.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0013-7227
pubmed:author
pubmed:issnType
Print
pubmed:volume
96
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
897-89
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Cellular localization of 5alpha-reductase and 3alpha-hydroxysteroid dehydrogenase in the seminiferous tubule of the rat testis.
pubmed:publicationType
Journal Article