Linked Life Data

11199287

Source:http://linkedlifedata.com/resource/pubmed/id/11199287

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2001-1-29
pubmed:abstractText
Alcoholism is a quantitative disorder that is caused by the combined influences of numerous genes (i.e., quantitative trait loci [QTLs]) and environmental factors. To identify QTLs for alcoholism, researchers compare subject groups (e.g., inbred mouse strains) that differ in both their genetic makeup (i.e., genotype) and alcohol-related trait (e.g., sensitivity to certain alcohol effects). Using statistical tests one can then determine whether a specific gene or DNA region contributes to the trait of interest. This strategy requires that the relevant gene exists in several variants (i.e., is polymorphic). To conduct such QTL analyses, researchers study either a large population of mice that all differ in their genotypes or compare several strains, each of which has a fixed genotype. However, QTL analyses still have several limitations. Nevertheless, such studies already have identified several DNA regions and genes that may affect the response to alcohol and thus may contribute to the risk for alcoholism.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1535-7414
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
169-74
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Quantitative trait locus analysis.
pubmed:affiliation
Department of Psychology, Furman University, Greenville, South Carolina, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review