|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2001-1-24
|
|
pubmed:abstractText |
Due to their chemical definition and reduced size, the use of peptides as gene delivery systems is gaining interest as compared to the more common polymeric non-viral vectors. To achieve gene transfer efficiencies that would make peptides a realistic alternative to existing methods, we have evaluated and attempted to concert those properties with a direct impact on the activity of the system. These considerations have led to the design, synthesis and characterization of a 23-residue cationic peptide which we term RAWA.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1099-498X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
2
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
455-64
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:11199266-3T3 Cells,
pubmed-meshheading:11199266-Amino Acid Sequence,
pubmed-meshheading:11199266-Animals,
pubmed-meshheading:11199266-COS Cells,
pubmed-meshheading:11199266-Cations,
pubmed-meshheading:11199266-Cell Membrane,
pubmed-meshheading:11199266-Cell Membrane Permeability,
pubmed-meshheading:11199266-DNA,
pubmed-meshheading:11199266-DNA, Recombinant,
pubmed-meshheading:11199266-DNA-Binding Proteins,
pubmed-meshheading:11199266-Luciferases,
pubmed-meshheading:11199266-Mice,
pubmed-meshheading:11199266-Molecular Sequence Data,
pubmed-meshheading:11199266-Oligopeptides,
pubmed-meshheading:11199266-Plasmids,
pubmed-meshheading:11199266-Protein Binding,
pubmed-meshheading:11199266-Transfection
|
|
pubmed:articleTitle |
An optimized amphiphilic cationic peptide as an efficient non-viral gene delivery vector.
|
|
pubmed:affiliation |
Department of Immunology and Oncology, Centro Nacional de Biotecnología, Universidad Autónoma de Madrid, Spain.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
