Linked Life Data

11199173

Source:http://linkedlifedata.com/resource/pubmed/id/11199173

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2001-1-29
pubmed:abstractText
The aim of this study was to evaluate the impact of combined exposure to lead and cadmium, used in hypertensive doses, on the reactivity of isolated mesenteric rat vessels to dopamine. Experiments were performed on 64 male Buffalo rats (195-245 g body weight) administered intragastrically with lead acetate (35 mg Pb/kg b.w.) and/or cadmium chloride (5 mg Cd/kg b.w.) once a week for seven weeks. The isolated mesenteric bed was prepared according to McGregor's method. Dopamine (800 micrograms) was injected before and during the infusion, one after the other, of angiotensin converting enzyme (0.0004 j/ml/min), ketoprofen (0.2 mg/ml/min), and losartan (0.05 mg/ml/min) or infusion of nitric oxide synthase blocker, N-omega-nitro-L-argine (22 micrograms/ml/min), verapamil (0.001 mg/ml/min), and then propranolol (0.3 mg/ml/min). The results show an unchanged, in comparison to controls, vascular effect of dopamine in lead and cadmium poisoned rats. However, these metals modified the reactivity of mesenteric vessels to endogenous angiotensin and prostaglandins mediated pressor action of dopamine.
pubmed:language
pol
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0465-5893
pubmed:author
pubmed:issnType
Print
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
435-45
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
[Function of dopamine in mesenteric blood vessels of rats poisoned with lead and cadmium].
pubmed:affiliation
Katedry i Kliniki Chorób Wewnetrznych i Zawodowych Akademii Medycznej we Wroc?awiu.
pubmed:publicationType
Journal Article, English Abstract