11196712

Source:http://linkedlifedata.com/resource/pubmed/id/11196712

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0012655, umls-concept:C0019409, umls-concept:C0021311, umls-concept:C0023276, umls-concept:C0026809, umls-concept:C0031437, umls-concept:C0439064, umls-concept:C1708726
pubmed:issue	3
pubmed:dateCreated	2001-1-24
pubmed:abstractText	Susceptibility as opposed to resistance of mouse strains (e.g., BALB/c vs C57BL/6) to Leishmania major has been attributed to a defective Th1 and a predominant Th2-response, resulting in increased IL-4 and IgE production, and decreased interferon gamma (IFN gamma) production, macrophage activation and elimination of parasites. Here we report dissection of genetic and functional aspects of susceptibility to leishmaniasis using two contrasting inbred strains BALB/cHeA (susceptible) and STS/A (resistant) and a resistant Recombinant Congenic (RC) Strain, CcS-5/Dem, which carries a random set of 12.5% of genes from the strain STS and 87.5% genes from the susceptible strain BALB/c. Linkage analysis of F2 hybrids between the resistant RC strain CcS-5 and the susceptible strain BALB/c revealed five loci affecting the response to the infection, each apparently associated with a different combination of pathological symptoms and immunological reactions. The correlation between Th2-type immune reactions and the disease in the F2 mice was either absent, or it was limited to mice with specific genotypes at loci on chromosomes 10 and 17. This suggests that the resistance vs susceptibility is influenced by mechanisms additional to the postulated antagonistic effects of Th1 and Th2 responses, and that the host's genotype affects the development of leishmaniasis in a complex way.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/100953417
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Feb
pubmed:issn	1466-4879
pubmed:author	pubmed-author:BadalováJJ, pubmed-author:DemantPP, pubmed-author:HartA AAA, pubmed-author:HavelkováHH, pubmed-author:HolánVV, pubmed-author:KrulováMM, pubmed-author:LipoldováMM, pubmed-author:NohýnkováEE, pubmed-author:SvobodováMM, pubmed-author:VolfPP
pubmed:issnType	Print
pubmed:volume	1
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	200-6
pubmed:dateRevised	2010-11-18
pubmed:meshHeading	pubmed-meshheading:11196712-Animals, pubmed-meshheading:11196712-Animals, Congenic, pubmed-meshheading:11196712-Female, pubmed-meshheading:11196712-Genetic Linkage, pubmed-meshheading:11196712-Genotype, pubmed-meshheading:11196712-Hybridization, Genetic, pubmed-meshheading:11196712-Leishmania major, pubmed-meshheading:11196712-Leishmaniasis, Cutaneous, pubmed-meshheading:11196712-Lymphocyte Activation, pubmed-meshheading:11196712-Mice, pubmed-meshheading:11196712-Mice, Inbred BALB C, pubmed-meshheading:11196712-Mice, Inbred C57BL, pubmed-meshheading:11196712-Mice, Inbred Strains, pubmed-meshheading:11196712-Phenotype, pubmed-meshheading:11196712-Polymorphism, Genetic, pubmed-meshheading:11196712-Species Specificity, pubmed-meshheading:11196712-Th1 Cells, pubmed-meshheading:11196712-Th2 Cells
pubmed:year	2000
pubmed:articleTitle	Susceptibility to Leishmania major infection in mice: multiple loci and heterogeneity of immunopathological phenotypes.
pubmed:affiliation	Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic. lipoldová@img.cas.cz
pubmed:publicationType	Journal Article, Comparative Study, In Vitro, Research Support, Non-U.S. Gov't