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rdf:type |
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lifeskim:mentions |
umls-concept:C0007577,
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0023745,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0185117,
umls-concept:C0205070,
umls-concept:C0205485,
umls-concept:C0405581,
umls-concept:C0678594,
umls-concept:C2911684
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pubmed:issue |
6
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pubmed:dateCreated |
2001-1-18
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pubmed:databankReference |
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pubmed:abstractText |
Isolation and characterization were performed for cDNA encoding mouse testicular cell adhesion molecule-1 (TCAM-1) using 2908 bases coding for a protein having 548 amino acids (60 kDa). Mouse TCAM-1 protein was found to consist of seven domains for signal sequence, five immunoglobulin (Ig) domains, and the transmembrane plus cytoplasmic domain. TCAM-1 gene and the region linking it to growth hormone (GH) gene located downstream from the TCAM-1 gene were then analyzed. The mouse TCAM-1 gene was 11.6 kb in length with 8 exons; the same as for the 12.0 kb rat gene. The distance from the TCAM-1 to GH gene was 12.5 kb in the mouse genome, and 7.6 kb in the rat. By Northern hybridization, 3.1-kb TCAM-1 mRNA was detected in 17-day testis and would appear present in pachytene spermatocytes and round spermatids.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0831-2796
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
957-62
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11195349-Amino Acid Sequence,
pubmed-meshheading:11195349-Animals,
pubmed-meshheading:11195349-Base Sequence,
pubmed-meshheading:11195349-Blotting, Northern,
pubmed-meshheading:11195349-Cell Adhesion Molecules,
pubmed-meshheading:11195349-Cloning, Molecular,
pubmed-meshheading:11195349-DNA, Complementary,
pubmed-meshheading:11195349-Gene Expression,
pubmed-meshheading:11195349-Genetic Linkage,
pubmed-meshheading:11195349-Growth Hormone,
pubmed-meshheading:11195349-Male,
pubmed-meshheading:11195349-Membrane Proteins,
pubmed-meshheading:11195349-Mice,
pubmed-meshheading:11195349-Mice, Inbred BALB C,
pubmed-meshheading:11195349-Molecular Sequence Data,
pubmed-meshheading:11195349-RNA, Messenger,
pubmed-meshheading:11195349-Sequence Homology, Amino Acid,
pubmed-meshheading:11195349-Testis
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pubmed:year |
2000
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pubmed:articleTitle |
Structure, expression, and conserved physical linkage of mouse testicular cell adhesion molecule-1 (TCAM-1) gene.
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pubmed:affiliation |
Department of Chemistry, College of Science, Rikkyo University, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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