Linked Life Data

1119523

Source:http://linkedlifedata.com/resource/pubmed/id/1119523

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1975-6-2
pubmed:abstractText
Administration of attenuated Mycobacterium bovis (Bacillus Calmette-Guérin or BCG) provides nonspecific resistance to a variety of microbial infections and tumors. This is associated with a state of augmented immunologic responsiveness. Mustering defenses against intracellular parasites, such as Toxoplasma gondii, presents a special problem that can be met only by measures that alter the intracellular environment. Our study was designed to evaluate the effect of prior immunization of rabbits with BCG on experimental toxoplasmic retinochoroiditis. One group of rabbits was immunized by the intravenous administration of BCG, another group by the retrobulbar injection of BCG, and a third group, unvaccinated, served as a control. Intravenous immunization provided significant protection against Toxoplasma organisms injected into the suprachoroidal space. In the immunized rabbits, the onset of Toxoplasma retinochoroiditis was delayed and the severity of the disease reduced. Although Toxoplasma was isolated from the chorioretinal tissues of both BCG-immunized and control rabbits, Toxoplasma antibody was not (with one exception) detected in the sera of BCG-immunized rabbits. While vaccination by the retrobulbar route produced little or no effect, intravenous administration of BCG provided nonspecific resistance to Toxoplasma retinochoroiditis in rabbits.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0002-9394
pubmed:author
pubmed:issnType
Print
pubmed:volume
79
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
641-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Effect of immunization with attenuated Mycobacterium bovis on experimental toxoplasmic retinochoroiditis.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.