Source:http://linkedlifedata.com/resource/pubmed/id/11193794
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2001-1-18
|
| pubmed:abstractText |
A central challenge of research on Alzheimer's disease (AD) is to assemble the enormous body of scientific observations about the disorder, some of them seemingly in conflict with others, into a coherent and credible mechanism of pathogenesis. In this article, I attempt to synthesize the disparate findings on AD into a unified sequence that essentially begins with alterations in the production or clearance of the amyloid beta-protein (A beta). Mounting evidence from many laboratories supports an A beta accumulation in limbic and association cortices as the fundamental initiator of the disease, with attendant therapeutic implications.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0077-8923
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
924
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
17-25
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:11193794-Alzheimer Disease,
pubmed-meshheading:11193794-Amyloid beta-Peptides,
pubmed-meshheading:11193794-Brain,
pubmed-meshheading:11193794-Cytotoxins,
pubmed-meshheading:11193794-Humans,
pubmed-meshheading:11193794-Neurofibrillary Tangles,
pubmed-meshheading:11193794-Plaque, Amyloid
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Toward a comprehensive theory for Alzheimer's disease. Hypothesis: Alzheimer's disease is caused by the cerebral accumulation and cytotoxicity of amyloid beta-protein.
|
| pubmed:affiliation |
Department of Neurology, Harvard Medical School, and Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. boucher@cnd.bwh.harvard.edu
|
| pubmed:publicationType |
Journal Article,
Review
|