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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1975-5-29
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pubmed:abstractText |
Morphological investigations by lightmicroscopy were performed to evaluate the influence of an altered liver RES-function state on the course of Gal-N-hepatitis. There was a good correlation between the biochemical data and the morphological alterations. The simultaneous infusion of Gal-N 1 g/kg b.w. and carbon particles (2.6 mg/100 g b.w) into the portal vein was followed by subtotal necrosis of the liver and Sanarelli-Shwartzmann-phenomenon. Signs of RES-activity were nearly absent. 8 days after pretreatment with carbon, Gal-N application did not produce Gal-N hepatitis; 21 days after carbon infusion the morphological changes normally found after Gal-N application were present. The morphological studies confirm the concept that an altered RES-function state is a very important factor for the development of liver cell necrosis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0300-970X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
29-35
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:1119301-Animals,
pubmed-meshheading:1119301-Carbon,
pubmed-meshheading:1119301-Drug-Induced Liver Injury,
pubmed-meshheading:1119301-Galactosamine,
pubmed-meshheading:1119301-Ink,
pubmed-meshheading:1119301-Kupffer Cells,
pubmed-meshheading:1119301-Liver,
pubmed-meshheading:1119301-Mononuclear Phagocyte System,
pubmed-meshheading:1119301-Necrosis,
pubmed-meshheading:1119301-Phagocytosis,
pubmed-meshheading:1119301-Premedication,
pubmed-meshheading:1119301-Rats,
pubmed-meshheading:1119301-Rats, Inbred Strains,
pubmed-meshheading:1119301-Shwartzman Phenomenon,
pubmed-meshheading:1119301-Time Factors
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pubmed:year |
1975
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pubmed:articleTitle |
Galactosamine- "hepatitis" in rats with different phagocytic activity of liver RES.
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pubmed:publicationType |
Journal Article
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