Source:http://linkedlifedata.com/resource/pubmed/id/11189018
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-3
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pubmed:dateCreated |
2001-1-19
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pubmed:abstractText |
The production of interleukin-1beta (IL-1beta) in brain is thought to be a critical step in the induction of central manifestations of the acute phase response, and the vagus nerve has been implicated in immune-to-brain communication. Thus, this study examined the effects of intraperitoneal (i.p.) injections of lipopolysaccharide (LPS) on brain IL-1beta protein levels in control and subdiaphragmatically vagotomized rats. In the first experiment, vagotomized and sham-operated male Sprague-Dawley rats were injected i.p. with one of three doses (10, 50, 100 microg/kg) of LPS or vehicle (sterile, pyrogen-free saline) and sacrificed 2 h after the injection. In the second experiment, vagotomized and sham-operated rats were injected i.p. with 100 microg/kg LPS or vehicle and sacrificed 1 h after the injection. The i.p. injection of LPS dose-dependently increased IL-1beta protein levels in the hypothalamus, hippocampus, dorsal vagal complex, cerebellum, posterior cortex, and pituitary 2 h after the injection. Brain and pituitary IL-1beta levels were also significantly increased 1 h after the injection of 100 microg/kg LPS. There were no significant differences in brain IL-1beta levels between sham-operated and vagotomized rats at either the 2 h or 1 h time points. The current data are consistent with previous studies showing increases in brain IL-1beta after peripheral injections of LPS, and support the notion that brain IL-1beta is a mediator in the illness-induction pathway. Furthermore, these data indicate that, at the doses and times tested, subdiaphragmatic vagal afferents are not crucial for LPS-induced brain IL-1beta protein.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1566-0702
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
85
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
119-26
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pubmed:dateRevised |
2009-8-12
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pubmed:meshHeading |
pubmed-meshheading:11189018-Animals,
pubmed-meshheading:11189018-Brain Chemistry,
pubmed-meshheading:11189018-Cerebellum,
pubmed-meshheading:11189018-Cerebral Cortex,
pubmed-meshheading:11189018-Cholecystokinin,
pubmed-meshheading:11189018-Eating,
pubmed-meshheading:11189018-Hippocampus,
pubmed-meshheading:11189018-Hypothalamus,
pubmed-meshheading:11189018-Injections, Intraperitoneal,
pubmed-meshheading:11189018-Interleukin-1,
pubmed-meshheading:11189018-Lipopolysaccharides,
pubmed-meshheading:11189018-Male,
pubmed-meshheading:11189018-Neuroimmunomodulation,
pubmed-meshheading:11189018-Pituitary Gland,
pubmed-meshheading:11189018-Rats,
pubmed-meshheading:11189018-Rats, Sprague-Dawley,
pubmed-meshheading:11189018-Vagotomy,
pubmed-meshheading:11189018-Vagus Nerve
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pubmed:year |
2000
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pubmed:articleTitle |
Effects of vagotomy on lipopolysaccharide-induced brain interleukin-1beta protein in rats.
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pubmed:affiliation |
Department of Psychology, University of Colorado at Boulder, 80309-0345, USA. mhansen@psych.colorado.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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