Linked Life Data

11187866

Source:http://linkedlifedata.com/resource/pubmed/id/11187866

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10 Suppl
pubmed:dateCreated
2001-1-12
pubmed:abstractText
Four epitopes in the factor VIII (FVIII) molecule have been identified that constitute the targets for antibodies in most inhibitor plasmas. These epitopes are located in the A2, A3 and C2 domains and in the activation peptide (ar3 region) of the FVIII light chain. We have developed a method for mapping FVIII epitopes using recombinant hybrid human/porcine FVIII molecules. Ongoing studies continue to provide higher resolution maps of these epitopes. The manipulation of inhibitor epitopes using recombinant DNA technology may lead to improved forms of FVIII that have lower antigenicity and/or lower immunogenicity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0390-6078
pubmed:author
pubmed:issnType
Print
pubmed:volume
85
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
26-8; discussion 28-30
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Mapping factor VIII inhibitor epitopes using hybrid human/porcine factor VIII molecules.
pubmed:affiliation
Department of Medicine, Emory University, Atlanta, GA 30322, USA. jlollar@emory.edu
pubmed:publicationType
Journal Article, Review