Source:http://linkedlifedata.com/resource/pubmed/id/11181144
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0008059,
umls-concept:C0021270,
umls-concept:C0021745,
umls-concept:C0021758,
umls-concept:C0035235,
umls-concept:C0039195,
umls-concept:C0085358,
umls-concept:C0871261,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1704632,
umls-concept:C1706438,
umls-concept:C1706817,
umls-concept:C2698600,
umls-concept:C2911692
|
| pubmed:issue |
5
|
| pubmed:dateCreated |
2001-2-22
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| pubmed:abstractText |
CD8+ cytotoxic T lymphocyte (CTL) activity, interferon (IFN)-gamma, and interleukin (IL)-4 production were evaluated in a blinded manner among respiratory syncytial virus (RSV)-infected newborns and their mothers for 3 epidemic seasons. Most mothers (80%) exhibited RSV-specific CD8+ CTL activity. Twenty (80%) of the 26 infants exhibited significant RSV-specific CTL activity during or after their first RSV season. CTL frequency increased with RSV infection rate, reaching 75% by the end of the third season. Most infants who shed virus (75%) had a medically attended lower respiratory tract disease (LRD). In the first year, RSV-infected infants (virus culture and antibody increase) were more likely to develop CTL activity (10 of 13) than were uninfected infants (1 of 5; P=.02). Infants with CTL activity in the first year were less likely to have an LRD in the second year. CD8+ CTL levels correlated positively with IFN-gamma (P<.001) and inversely with IL-4 (P=.03). Contribution of CD8+ CTL and IFN-gamma in the control of RSV disease in infants and children is implicated.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
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| pubmed:issn |
0022-1899
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
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| pubmed:volume |
183
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
687-96
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:11181144-Adult,
pubmed-meshheading:11181144-Antibodies, Viral,
pubmed-meshheading:11181144-Antigens, Viral,
pubmed-meshheading:11181144-CD8-Positive T-Lymphocytes,
pubmed-meshheading:11181144-Child, Preschool,
pubmed-meshheading:11181144-Cohort Studies,
pubmed-meshheading:11181144-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:11181144-Female,
pubmed-meshheading:11181144-Humans,
pubmed-meshheading:11181144-Infant,
pubmed-meshheading:11181144-Infant, Newborn,
pubmed-meshheading:11181144-Interferon-gamma,
pubmed-meshheading:11181144-Interleukin-4,
pubmed-meshheading:11181144-Male,
pubmed-meshheading:11181144-Respiratory Syncytial Virus, Human,
pubmed-meshheading:11181144-Respiratory Syncytial Virus Infections,
pubmed-meshheading:11181144-Seasons,
pubmed-meshheading:11181144-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:11181144-Texas
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
HLA-restricted CD8+ cytotoxic T lymphocyte, interferon-gamma, and interleukin-4 responses to respiratory syncytial virus infection in infants and children.
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| pubmed:affiliation |
Influenza Research Center, Respiratory Pathogens Research Unit, Dept. of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA. mbawuike@bcm.tmc.edu
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|