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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2001-2-22
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pubmed:databankReference |
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pubmed:abstractText |
Vertebrates exhibit a variety of sex determining mechanisms which fall broadly into two classes: environmental or genetic. In birds and mammals sex is determined by a genetic mechanism. In mammals males are the heterogametic sex (XY) with the Y chromosome acting as a dominant determiner of sex due to the action of the testis-determining factor, SRY. In birds females are the heterogametic sex (ZW); however, it is not known whether the W chromosome carries a dominant ovary-determining gene, or whether Z chromosome dosage determines sex. Using an experimental approach, which assumes only that the sex-determining event in birds is accompanied by sex-specific changes in gene expression, we have identified a novel gene, ASW (Avian Sex-specific W-linked). The putative protein for ASW is related to the HIT (histidine triad) family of proteins. ASW shows female-specific expression in genital ridges and maps to the chicken W chromosome. In addition, we show that, with the exception of ratites, ASW is linked to the W chromosome in each of 17 bird species from nine different families of the class Aves.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0949-944X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
210
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
243-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:11180828-Amino Acid Sequence,
pubmed-meshheading:11180828-Animals,
pubmed-meshheading:11180828-Avian Proteins,
pubmed-meshheading:11180828-Base Sequence,
pubmed-meshheading:11180828-Blotting, Southern,
pubmed-meshheading:11180828-Chick Embryo,
pubmed-meshheading:11180828-Cloning, Molecular,
pubmed-meshheading:11180828-Conserved Sequence,
pubmed-meshheading:11180828-Female,
pubmed-meshheading:11180828-Gene Expression Regulation, Developmental,
pubmed-meshheading:11180828-Gene Library,
pubmed-meshheading:11180828-Genetic Linkage,
pubmed-meshheading:11180828-Gonads,
pubmed-meshheading:11180828-Hydrolases,
pubmed-meshheading:11180828-In Situ Hybridization,
pubmed-meshheading:11180828-Molecular Sequence Data,
pubmed-meshheading:11180828-Physical Chromosome Mapping,
pubmed-meshheading:11180828-Proteins,
pubmed-meshheading:11180828-RNA, Messenger,
pubmed-meshheading:11180828-Sequence Alignment,
pubmed-meshheading:11180828-Sequence Analysis,
pubmed-meshheading:11180828-Sex Characteristics,
pubmed-meshheading:11180828-Sex Chromosomes,
pubmed-meshheading:11180828-Sex Determination Processes,
pubmed-meshheading:11180828-Songbirds
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pubmed:year |
2000
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pubmed:articleTitle |
ASW: a gene with conserved avian W-linkage and female specific expression in chick embryonic gonad.
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pubmed:affiliation |
Department of Paediatrics and Centre for Hormone Research, University of Melbourne, Royal Children's Hospital, Melbourne, Victoria 3052, Australia. sinclair@cryptic.rch.unimelb.edu.a
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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