Source:http://linkedlifedata.com/resource/pubmed/id/11180674
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2001-2-22
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| pubmed:abstractText |
SUMMARY. To evaluate the importance of a past history of asthma-like symptoms over a period of 2 years and current bronchial hyperreactivity (BHR), 538 randomly selected schoolchildren, initially aged 7-8 years, were examined. At yearly intervals, three standardized questionnaires, including items from the ISAAC panel, were answered by parents. Following the last questionnaire, BHR to 4.5% hypertonic saline (HS) was recorded. In survey 1, lifetime prevalence of asthma was 4.9%. During the 12-month period, prevalence of wheeze and dyspnea ranged between 9.3 and 5.2% (Survey 1) and 5.9% and 4.4% (Survey 2). Among children with wheeze or dyspnea in Survey 3, BHR (defined as a fall of baseline FEV(1) > or = 15%) was significantly more frequent (50.0% and 60.7%, respectively) than among children without these symptoms (12.8%, P < 0.001, and 12.8%, P < 0.001, respectively). The negative predictive value of BHR to have neither wheeze nor dyspnea was about 88% and did not vary throughout the study (Survey 1, 87%; Survey 2, 88%; Survey 3, 88%). The relative risk of showing BHR was significantly increased in children with wheeze (survey 2, odds ratio (OR) 3.0 (95% confidence interval (CI) 1.0-8.7)) or dyspnea (Survey 1: OR 5.9 (95% CI 1.9-18.5), Survey 3: 5.2 (1.7-16.2), but not in children with dry cough or nocturnal cough (data not shown). Wheeze and dyspnea occurred repeatedly in the same individuals with BHR in a high percentage of children (83.3% and 76.5%, respectively). In conclusion, there is a strong association between recent and previous dyspnea and current BHR, and it indicates intraindividual persistence of symptom history.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
8755-6863
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2001 Wiley-Liss, Inc.
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| pubmed:issnType |
Print
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| pubmed:volume |
31
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
44-50
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11180674-Asthma,
pubmed-meshheading:11180674-Bronchial Hyperreactivity,
pubmed-meshheading:11180674-Bronchial Provocation Tests,
pubmed-meshheading:11180674-Child,
pubmed-meshheading:11180674-Confidence Intervals,
pubmed-meshheading:11180674-Cough,
pubmed-meshheading:11180674-Dyspnea,
pubmed-meshheading:11180674-Female,
pubmed-meshheading:11180674-Follow-Up Studies,
pubmed-meshheading:11180674-Forced Expiratory Volume,
pubmed-meshheading:11180674-Humans,
pubmed-meshheading:11180674-Logistic Models,
pubmed-meshheading:11180674-Longitudinal Studies,
pubmed-meshheading:11180674-Male,
pubmed-meshheading:11180674-Odds Ratio,
pubmed-meshheading:11180674-Predictive Value of Tests,
pubmed-meshheading:11180674-Prevalence,
pubmed-meshheading:11180674-Questionnaires,
pubmed-meshheading:11180674-Respiratory Sounds,
pubmed-meshheading:11180674-Risk Factors,
pubmed-meshheading:11180674-Saline Solution, Hypertonic,
pubmed-meshheading:11180674-Statistics, Nonparametric,
pubmed-meshheading:11180674-Vital Capacity
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| pubmed:year |
2001
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| pubmed:articleTitle |
Bronchial hyperresponsiveness to 4.5% hypertonic saline indicates a past history of asthma-like symptoms in children.
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| pubmed:affiliation |
University Children's Hospital, Freiburg, Germany.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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