Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-2-22
pubmed:abstractText
Vimang is an aqueous extract of Mangifera indica used in Cuba to improve the quality of life in patients suffering from elevated stress. To assess its possible analgesic and antiinflammatory effects, the results of a standard extract evaluation are presented. Analgesia was determined using acetic acid-induced abdominal constriction and formalin-induced licking. Antiinflammatory effects were evaluated using carrageenan- and formalin-induced oedema. Vimang (50-1000 mg/kg, p.o.) exhibited a potent and dose-dependent antinociceptive effect against acetic acid test in mice. The mean potency (DE(50)) was 54.5 mg/kg and the maximal inhibition attained was 94.4%. Vimang (20-1000 mg/kg, p.o.) dose-dependently inhibited the second phase of formalin-induced pain but not the first phase. The DE(50) of the second phase was 8.4 mg/kg and the maximal inhibition was 99.5%, being more potent than indomethacin at doses of 20 mg/kg. Vimang (20-1000 mg/kg, p.o.) significantly inhibited oedema formation (p < 0.01 or p < 0.05) of both carrageenan- and formalin-induced oedema in rat, guinea-pigs and mice (maximal inhibitions: 39.5, 45.0 and 48.6, respectively). The inhibitions were similar to those produced by indomethacin and sodium naproxen, p.o. The different polyphenols found in Vimang could account for the antinociceptive and antiinflammatory actions reported here for the first time for M. indica bark aqueous extract.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0951-418X
pubmed:author
pubmed:copyrightInfo
Copyright 2001 John Wiley & Sons, Ltd.
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
18-21
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11180516-Acetic Acid, pubmed-meshheading:11180516-Analgesics, pubmed-meshheading:11180516-Animals, pubmed-meshheading:11180516-Anti-Inflammatory Agents, pubmed-meshheading:11180516-Carrageenan, pubmed-meshheading:11180516-Dose-Response Relationship, Drug, pubmed-meshheading:11180516-Edema, pubmed-meshheading:11180516-Female, pubmed-meshheading:11180516-Formaldehyde, pubmed-meshheading:11180516-Guinea Pigs, pubmed-meshheading:11180516-Male, pubmed-meshheading:11180516-Mice, pubmed-meshheading:11180516-Mice, Inbred Strains, pubmed-meshheading:11180516-Pain, pubmed-meshheading:11180516-Pain Measurement, pubmed-meshheading:11180516-Plant Extracts, pubmed-meshheading:11180516-Plants, Medicinal, pubmed-meshheading:11180516-Rats, pubmed-meshheading:11180516-Rats, Sprague-Dawley, pubmed-meshheading:11180516-Rosales
pubmed:year
2001
pubmed:articleTitle
Analgesic and anti-inflammatory effects of Mangifera indica L. extract (Vimang).
pubmed:affiliation
Centro de Química Farmacéutica, P.O. Box 16042, Atabey, Playa, Ciudad de La Habana (Havana City), Cuba. cqf@infomed.sld.cu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't