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rdf:type |
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lifeskim:mentions |
umls-concept:C0003955,
umls-concept:C0008357,
umls-concept:C0021311,
umls-concept:C0021756,
umls-concept:C0042196,
umls-concept:C0086418,
umls-concept:C0301625,
umls-concept:C0332281,
umls-concept:C0442027,
umls-concept:C0871261,
umls-concept:C0961644,
umls-concept:C1548795,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
3
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pubmed:dateCreated |
2001-2-26
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pubmed:abstractText |
To investigate the potential immunomodulatory effects of concurrent ascariasis on the cytokine response to a live oral vaccine, we measured cytokine responses to cholera toxin B subunit (CT-B) following vaccination with the live oral cholera vaccine CVD 103-HgR in Ascaris lumbricoides-infected subjects randomized in a double-blind study to receive two doses of either albendazole or placebo prior to vaccination and in a group of healthy U.S. controls. Postvaccination cytokine responses to CT-B were characterized by transient increases in the production of interleukin-2 (IL-2; P = 0.02) and gamma interferon (IFN-gamma; P = 0.001) in the three study groups combined; however, postvaccination increases in IFN-gamma were significant only in the albendazole-treated A. lumbricoides infection group (P = 0.008). Postvaccination levels of IL-2 were significantly greater in the albendazole-treated group compared with the placebo group (P = 0.03). No changes in levels of Th1 and Th2 cytokines in response to control ascaris antigens were observed over the same period. These findings indicate that vaccination with CVD 103-HgR is associated with a Th1 cytokine response (IL-2 and IFN-gamma) to CT-B, that infection with A. lumbricoides diminishes the magnitude of this response, and that albendazole treatment prior to vaccination was able to partially reverse the deficit in IL-2. The potential modulation of the immune response to oral vaccines by geohelminth parasites has important implications for the design of vaccination campaigns in geohelminth-endemic areas.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-10098329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-10515838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-10979918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-10979919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-1350292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-1355798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-1533656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-1583321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-1660184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-1833201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-1905327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-1948266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-3701119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-4342327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-5086050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-7845707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-7876613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-7930742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-7974657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-7975832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-8094248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-8115177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-8187332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-8303943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-8370397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-8376936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-8409444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-8423098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-8438610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-8537675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-9002329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-9230725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-9806045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11179329-9952390
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1574-80
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11179329-Adult,
pubmed-meshheading:11179329-Albendazole,
pubmed-meshheading:11179329-Animals,
pubmed-meshheading:11179329-Anthelmintics,
pubmed-meshheading:11179329-Antigens, Helminth,
pubmed-meshheading:11179329-Ascariasis,
pubmed-meshheading:11179329-Ascaris lumbricoides,
pubmed-meshheading:11179329-Cholera,
pubmed-meshheading:11179329-Cholera Toxin,
pubmed-meshheading:11179329-Cholera Vaccines,
pubmed-meshheading:11179329-Double-Blind Method,
pubmed-meshheading:11179329-Female,
pubmed-meshheading:11179329-Humans,
pubmed-meshheading:11179329-Interferon-gamma,
pubmed-meshheading:11179329-Interleukin-2,
pubmed-meshheading:11179329-Leukocytes, Mononuclear,
pubmed-meshheading:11179329-Male,
pubmed-meshheading:11179329-Vaccination
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pubmed:year |
2001
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