Source:http://linkedlifedata.com/resource/pubmed/id/11179053
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2001-2-22
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| pubmed:abstractText |
The interaction between the cardioprotective effect of endothelin (ET) receptor blockade and nitric oxide (NO) during ischemia-reperfusion injury was investigated. Anesthetized pigs were subjected to 45 (protocol 1) or 30 min (protocol 2) coronary artery ligation and 4 h reperfusion. In protocol 1, five groups were given vehicle, the ET(A) receptor antagonist LU-135252 (LU), the NO synthase (NOS) inhibitor N(G)-nitro-L-arginine (L-NNA), L-NNA in combination with LU, or L-NNA in combination with the NO precursor L-arginine (L-Arg) and LU intravenously before ischemia. In protocol 2, two groups were given vehicle or L-NNA. In protocol 1, the infarct size (IS) was 79 +/- 5% of the area at risk in the vehicle group and 93 +/- 2% in the L-NNA group. LU reduced the IS to 43 +/- 7% (P < 0.001). The cardioprotective effect of LU was abolished in the presence of L-NNA (IS 76 +/- 6%), whereas addition of L-Arg restored its cardioprotective effect (IS 56 +/- 2%; P < 0.05 vs. vehicle and L-NNA + LU groups). In protocol 2, the IS was 49 +/- 6% in the vehicle group and 32 +/- 4% in the L-NNA group (P = not significant). Myocardial ET-like immunoreactivity (ET-LI) increased in the vehicle group of protocol 1. ET-LI in the ischemic-reperfused myocardium was lower in the groups given LU (P < 0.01) and L-NNA + L-Arg + LU (P < 0.05) but not in the group given L-NNA + LU compared with the vehicle group. These results suggest that the cardioprotective effect of the ET(A) receptor antagonist is mediated via a mechanism related to NO.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Endothelin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/LU 135252,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitroarginine,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylpropionates,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Endothelin A,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Endothelin
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| pubmed:status |
MEDLINE
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| pubmed:month |
Mar
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| pubmed:issn |
0363-6135
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
280
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
H1105-12
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11179053-Animals,
pubmed-meshheading:11179053-Blood Pressure,
pubmed-meshheading:11179053-Coronary Circulation,
pubmed-meshheading:11179053-Endothelin-1,
pubmed-meshheading:11179053-Enzyme Inhibitors,
pubmed-meshheading:11179053-Female,
pubmed-meshheading:11179053-Heart Rate,
pubmed-meshheading:11179053-Male,
pubmed-meshheading:11179053-Myocardial Infarction,
pubmed-meshheading:11179053-Myocardial Reperfusion Injury,
pubmed-meshheading:11179053-Nitric Oxide,
pubmed-meshheading:11179053-Nitric Oxide Synthase,
pubmed-meshheading:11179053-Nitroarginine,
pubmed-meshheading:11179053-Phenylpropionates,
pubmed-meshheading:11179053-Pyrimidines,
pubmed-meshheading:11179053-Receptor, Endothelin A,
pubmed-meshheading:11179053-Receptors, Endothelin,
pubmed-meshheading:11179053-Survival Rate,
pubmed-meshheading:11179053-Swine
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| pubmed:year |
2001
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| pubmed:articleTitle |
Involvement of nitric oxide in cardioprotective effect of endothelin receptor antagonist during ischemia-reperfusion.
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| pubmed:affiliation |
Department of Cardiology, Karolinska Hospital, Stockholm, S-171 76 Sweden. agourine@hotmail.com
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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