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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-2-22
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pubmed:abstractText |
Manipulation or non-physiological embryo culture environments can lead to defective fetal programming in livestock. Our demonstration of reduced fetal methylation and expression of ovine IGF2R suggests pre-implantation embryo procedures may be vulnerable to epigenetic alterations in imprinted genes. This highlights the potential benefits of epigenetic diagnostic screening in developing embryo procedures.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1061-4036
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
153-4
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11175780-Abnormalities, Multiple,
pubmed-meshheading:11175780-Animals,
pubmed-meshheading:11175780-Blastocyst,
pubmed-meshheading:11175780-Cloning, Organism,
pubmed-meshheading:11175780-Congenital Abnormalities,
pubmed-meshheading:11175780-DNA Methylation,
pubmed-meshheading:11175780-Embryonic and Fetal Development,
pubmed-meshheading:11175780-Female,
pubmed-meshheading:11175780-Genetic Testing,
pubmed-meshheading:11175780-Genomic Imprinting,
pubmed-meshheading:11175780-Pregnancy,
pubmed-meshheading:11175780-Receptor, IGF Type 2,
pubmed-meshheading:11175780-Sheep
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pubmed:year |
2001
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pubmed:articleTitle |
Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture.
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pubmed:affiliation |
Roslin Institute (Edinburgh), Roslin, Midlothian, Scotland, UK. Lorraine.Young@bbsrc.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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