11174470

pubmed:Citation

2

A number of previous investigations showed significant associations between polymorphisms of the vitamin D receptor (VDR) gene and bone mineral density (BMD). BMD is influenced by hormones and the rate of skeletal remodeling. A study was performed to investigate the possible relationship between Apa I, Bsm I, Taq I, and Fok I polymorphisms of the VDR gene and serum 1,25-dihydroxyvitamin D (1,25[OH]2D), osteocalcin, and propeptide of type I collagen (PICP)-markers of bone turnover, total body calcium, and BMD of the total body, radius, lumbar spine, trochanter, and femoral neck-in 39 young adult black men of 20 to 40 years of age and 44 age-, height-, and weight-matched white men. The distribution of each of the four alleles of the VDR genotypes was similar in the two racial groups. The Apa I VDR genotype was associated with serum PICP (P =.0494) but not with serum 1,25(OH)2D or serum osteocalcin. A significant association between the Apa I VDR genotype and BMD of the lumbar spine (P =.0291) was also observed. However, the Bsm I, Taq I, and Fok I genotypes were not significantly associated with BMD or serum osteocalcin, PICP, or 1,25(OH)2D. Multivariate stepwise analysis indicated that (1) the Apa I VDR genotype was associated with BMD of the lumbar spine in the two groups together; with total body calcium and BMD of the total body, radius, trochanter, and femoral neck in the black men; and with BMD of the radius in the white men; analysis also indicated that (2) race was significantly associated with total body calcium and BMD of the total body, lumbar spine, and femoral neck. In summary, the Apa I VDR genotype is associated with serum PICP and BMD at a number of sites but does not contribute to or account for racial differences in BMD in young adult men.

eng

AIM

MEDLINE

0022-2143

Print

NLM

133-40

pubmed-meshheading:11174470-Adult, pubmed-meshheading:11174470-African Continental Ancestry Group, pubmed-meshheading:11174470-Alleles, pubmed-meshheading:11174470-Biological Markers, pubmed-meshheading:11174470-Bone Density, pubmed-meshheading:11174470-Bone Remodeling, pubmed-meshheading:11174470-Calcitriol, pubmed-meshheading:11174470-Calcium, pubmed-meshheading:11174470-Continental Population Groups, pubmed-meshheading:11174470-Deoxyribonucleases, Type II Site-Specific, pubmed-meshheading:11174470-European Continental Ancestry Group, pubmed-meshheading:11174470-Genotype, pubmed-meshheading:11174470-Humans, pubmed-meshheading:11174470-Lumbar Vertebrae, pubmed-meshheading:11174470-Male, pubmed-meshheading:11174470-Osteocalcin, pubmed-meshheading:11174470-Peptide Fragments, pubmed-meshheading:11174470-Polymorphism, Restriction Fragment Length, pubmed-meshheading:11174470-Procollagen, pubmed-meshheading:11174470-Receptors, Calcitriol

ApaI polymorphisms of the vitamin D receptor predict bone density of the lumbar spine and not racial difference in bone density in young men.

Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.