Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-2-22
pubmed:abstractText
Squamous cell vulvar carcinoma accounts for 4% of all gynecologic malignancies. The cause of vulvar cancer is still unclear. Identification of new biologic factors involved in vulvar carcinogenesis may be useful in clarifying the natural history of this malignancy. We investigated the immunohistochemical expression of the retinoblastoma-related proteins pRB2/p130 and CKI p27kip1 in a series of 51 invasive squamous cell carcinomas of the vulva (ISCCs) and in synchronous normal vulvar skin, non-neoplastic epithelial disorders (NNED) and vulvar intraepithelial neoplasia (VIN). Normal vulvar skin staining showed positivity for both pRB2/p130 and p27kip1. Loss of pRB2/p130 occurred in 29 (57%) of 51 specimens of ISCCs, and in 1 of 7 specimens with VIN (14%; P = .04). We also observed a significant decrease of pRB2/p130 expression from NNED to neoplastic tissues (VIN and ISCCs) (P = .004). Loss of p27kip1 expression was found in 16 of 51 specimens (31%) of invasive carcinomas, in 1 (14%) of 7 specimens of VIN, and in 2 of 18 specimens of NNED (11%). pRB2/p130 and p27(kip1) did not correlate significantly with any of the clinicopathologic parameters examined. Our data indicate that loss of pRB2/p130 and p27kip1 are frequent events in invasive vulvar carcinomas compared with synchronous premalignant lesions, non-neoplastic epithelial disorders, and normal vulvar skin. The significant progressive decrease of pRB2/p130 expression from non-neoplastic epithelial alterations through intraepithelial neoplasia to invasive vulvar carcinomas suggests a role for this tumor suppressor gene in vulvar carcinogenesis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0046-8177
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:11172288-Aged, pubmed-meshheading:11172288-Carcinoma, Squamous Cell, pubmed-meshheading:11172288-Cell Cycle Proteins, pubmed-meshheading:11172288-Cyclin-Dependent Kinase Inhibitor p27, pubmed-meshheading:11172288-Female, pubmed-meshheading:11172288-Humans, pubmed-meshheading:11172288-Immunohistochemistry, pubmed-meshheading:11172288-Microtubule-Associated Proteins, pubmed-meshheading:11172288-Middle Aged, pubmed-meshheading:11172288-Neoplasm Invasiveness, pubmed-meshheading:11172288-Phosphoproteins, pubmed-meshheading:11172288-Proteins, pubmed-meshheading:11172288-Retinoblastoma-Like Protein p130, pubmed-meshheading:11172288-Skin Diseases, pubmed-meshheading:11172288-Tumor Suppressor Proteins, pubmed-meshheading:11172288-Vulva, pubmed-meshheading:11172288-Vulvar Diseases, pubmed-meshheading:11172288-Vulvar Neoplasms
pubmed:year
2001
pubmed:articleTitle
Expression of cell-cycle-associated proteins pRB2/p130 and p27kip in vulvar squamous cell carcinomas.
pubmed:affiliation
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't