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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2001-2-26
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pubmed:abstractText |
The binding of killer cell Ig-like Receptors (KIR) to their Class I MHC ligands was shown previously to be characterized by extremely rapid association and dissociation rate constants. During experiments to investigate the biochemistry of receptor-ligand binding in more detail, the kinetic parameters of the interaction were observed to alter dramatically in the presence of Zn(2+) but not other divalent cations. The basis of this phenomenon is Zn(2+)-induced multimerization of the KIR molecules as demonstrated by BIAcore, analytical ultracentrifugation, and chemical cross-linking experiments. Zn(2+)-dependent multimerization of KIR may be critical for formation of the clusters of KIR and HLA-C molecules, the "natural killer (NK) cell immune synapse," observed at the site of contact between the NK cell and target cell.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11172020-10410796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11172020-10497191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11172020-10611338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11172020-10816589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11172020-10831600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11172020-2147946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11172020-7594568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11172020-7650491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11172020-7836913,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11172020-8120376,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11172020-8265660,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11172020-8340759,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11172020-8627176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11172020-8692965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11172020-8806078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11172020-9059896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11172020-9126935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11172020-9164921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11172020-9190115,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/11172020-9490415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11172020-9670929,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/11172020-9826699
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
13
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pubmed:volume |
98
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1734-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11172020-HLA-C Antigens,
pubmed-meshheading:11172020-Histocompatibility Antigens Class I,
pubmed-meshheading:11172020-Humans,
pubmed-meshheading:11172020-Killer Cells, Natural,
pubmed-meshheading:11172020-Kinetics,
pubmed-meshheading:11172020-Magnesium,
pubmed-meshheading:11172020-Receptors, Immunologic,
pubmed-meshheading:11172020-Receptors, KIR,
pubmed-meshheading:11172020-Zinc
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pubmed:year |
2001
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pubmed:articleTitle |
The role of zinc in the binding of killer cell Ig-like receptors to class I MHC proteins.
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pubmed:affiliation |
Department of Pathology, Cambridge University, Tennis Court Road, Cambridge CB2 1QP, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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