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rdf:type |
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lifeskim:mentions |
umls-concept:C0002270,
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0086418,
umls-concept:C1171362,
umls-concept:C1416935,
umls-concept:C1514562,
umls-concept:C1515670,
umls-concept:C1880022,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221
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pubmed:issue |
3
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pubmed:dateCreated |
2001-2-22
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pubmed:databankReference |
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pubmed:abstractText |
We have identified the first gene lying on the centromeric side of the alpha-globin gene cluster on human 16p13.3. The gene, called 16pHQG;16 (HGMW-approved symbol LUC7L), is widely transcribed and lies in the opposite orientation with respect to the alpha-globin genes. This gene may represent a mammalian heterochromatic gene, encoding a putative RNA-binding protein similar to the yeast Luc7p subunit of the U1 snRNP splicing complex that is normally required for 5' splice site selection. To examine the role of the 16pHQG;16 gene in delimiting the extent of the alpha-globin regulatory domain, we mapped its mouse orthologue, which we found to lie on mouse chromosome 17, separated from the mouse alpha-cluster on chromosome 11. Establishing the full extent of the human 16pHQG;16 gene has allowed us to define the centromeric limit of the region of conserved synteny around the human alpha-globin cluster to within an 8-kb segment of chromosome 16.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0888-7543
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2001 Academic Press.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
307-14
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11170747-Alternative Splicing,
pubmed-meshheading:11170747-Amino Acid Sequence,
pubmed-meshheading:11170747-Animals,
pubmed-meshheading:11170747-Blotting, Northern,
pubmed-meshheading:11170747-Blotting, Southern,
pubmed-meshheading:11170747-CHO Cells,
pubmed-meshheading:11170747-Cell Line,
pubmed-meshheading:11170747-Centromere,
pubmed-meshheading:11170747-Chromosomes, Human, Pair 16,
pubmed-meshheading:11170747-Chromosomes, Human, Pair 17,
pubmed-meshheading:11170747-Conserved Sequence,
pubmed-meshheading:11170747-Cricetinae,
pubmed-meshheading:11170747-Evolution, Molecular,
pubmed-meshheading:11170747-Exons,
pubmed-meshheading:11170747-Globins,
pubmed-meshheading:11170747-Humans,
pubmed-meshheading:11170747-Introns,
pubmed-meshheading:11170747-Mice,
pubmed-meshheading:11170747-Models, Genetic,
pubmed-meshheading:11170747-Molecular Sequence Data,
pubmed-meshheading:11170747-Protein Structure, Tertiary,
pubmed-meshheading:11170747-RNA, Messenger,
pubmed-meshheading:11170747-RNA Splicing,
pubmed-meshheading:11170747-RNA-Binding Proteins,
pubmed-meshheading:11170747-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:11170747-Ribonucleoproteins, Small Nuclear,
pubmed-meshheading:11170747-Sequence Homology, Amino Acid,
pubmed-meshheading:11170747-Telomere,
pubmed-meshheading:11170747-Tissue Distribution,
pubmed-meshheading:11170747-Transcription, Genetic
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pubmed:year |
2001
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pubmed:articleTitle |
Characterization of a widely expressed gene (LUC7-LIKE; LUC7L) defining the centromeric boundary of the human alpha-globin domain.
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pubmed:affiliation |
MRC Molecular Haematology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, OX3 9DS, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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