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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-2-22
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pubmed:abstractText |
The Cox proportional hazards model restricts the hazard ratio to be linear in the covariates. A survival model based on data from a clinical trial is developed using spline functions with variable knots to estimate the log hazard function. Moreover, the main point of the method is that a knot, seen as free parameters for a piecewise linear spline, represents a break point in the log hazard function which may be interpreted as a threshold value. The likelihood ratio test is used to select the final model and to determine the threshold number for a covariate. Confidence intervals for these threshold values are computed by bootstrapping the data. Two examples illustrate the method.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0277-6715
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2001 John Wiley & Sons, Ltd.
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
237-47
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11169599-Carcinoma, Small Cell,
pubmed-meshheading:11169599-Clinical Trials as Topic,
pubmed-meshheading:11169599-Confidence Intervals,
pubmed-meshheading:11169599-Data Interpretation, Statistical,
pubmed-meshheading:11169599-Female,
pubmed-meshheading:11169599-Heart Transplantation,
pubmed-meshheading:11169599-Humans,
pubmed-meshheading:11169599-Likelihood Functions,
pubmed-meshheading:11169599-Lung Neoplasms,
pubmed-meshheading:11169599-Male,
pubmed-meshheading:11169599-Numerical Analysis, Computer-Assisted,
pubmed-meshheading:11169599-Phosphopyruvate Hydratase,
pubmed-meshheading:11169599-Prognosis,
pubmed-meshheading:11169599-Proportional Hazards Models,
pubmed-meshheading:11169599-Regression Analysis,
pubmed-meshheading:11169599-Survival Analysis
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pubmed:year |
2001
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pubmed:articleTitle |
Regression splines for threshold selection in survival data analysis.
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pubmed:affiliation |
Laboratoire de Biostatistique, Institut Universitaire de Recherche Clinique, 641, avenue Gaston Giraud, 34093 Montpellier, France.
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pubmed:publicationType |
Journal Article
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