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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2001-2-9
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pubmed:abstractText |
Reactive oxygen species (ROS) induce HSCs activation, proliferation and collagen gene expression in vitro. Nitric oxide (NO) represents a reactive molecule that reacts with ROS, yielding peroxynitrite. We thus verified the effect of NO on ROS-induced HSCs proliferation in vitro and correlated iNOS expression and ROS formation to HSCs activation in the early phase of liver injury leading to hepatic fibrosis in vivo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Ascorbic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Dimethylnitrosamine,
http://linkedlifedata.com/resource/pubmed/chemical/Free Radicals,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nos2 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Penicillamine,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/S-Nitroso-N-Acetylpenicillamine
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0106-9543
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-12
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11169066-Animals,
pubmed-meshheading:11169066-Ascorbic Acid,
pubmed-meshheading:11169066-Cell Division,
pubmed-meshheading:11169066-Cells, Cultured,
pubmed-meshheading:11169066-Dimethylnitrosamine,
pubmed-meshheading:11169066-Disease Models, Animal,
pubmed-meshheading:11169066-Drug Interactions,
pubmed-meshheading:11169066-Free Radicals,
pubmed-meshheading:11169066-Immunohistochemistry,
pubmed-meshheading:11169066-Liver,
pubmed-meshheading:11169066-Liver Cirrhosis,
pubmed-meshheading:11169066-Male,
pubmed-meshheading:11169066-Neutrophils,
pubmed-meshheading:11169066-Nitric Oxide,
pubmed-meshheading:11169066-Nitric Oxide Synthase,
pubmed-meshheading:11169066-Nitric Oxide Synthase Type II,
pubmed-meshheading:11169066-Penicillamine,
pubmed-meshheading:11169066-Rats,
pubmed-meshheading:11169066-Rats, Sprague-Dawley,
pubmed-meshheading:11169066-Reactive Oxygen Species,
pubmed-meshheading:11169066-S-Nitroso-N-Acetylpenicillamine
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pubmed:year |
2001
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pubmed:articleTitle |
Involvement of reactive oxygen species and nitric oxide radicals in activation and proliferation of rat hepatic stellate cells.
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pubmed:affiliation |
Department of Gastroenterology, University of Ancona, Italy. gsvegliati@unian.it
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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