| pubmed-article:11168828 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11168828 | lifeskim:mentions | umls-concept:C0019682 | lld:lifeskim |
| pubmed-article:11168828 | lifeskim:mentions | umls-concept:C1537056 | lld:lifeskim |
| pubmed-article:11168828 | lifeskim:mentions | umls-concept:C0020971 | lld:lifeskim |
| pubmed-article:11168828 | lifeskim:mentions | umls-concept:C0024400 | lld:lifeskim |
| pubmed-article:11168828 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
| pubmed-article:11168828 | lifeskim:mentions | umls-concept:C0314603 | lld:lifeskim |
| pubmed-article:11168828 | lifeskim:mentions | umls-concept:C1514562 | lld:lifeskim |
| pubmed-article:11168828 | lifeskim:mentions | umls-concept:C1883221 | lld:lifeskim |
| pubmed-article:11168828 | lifeskim:mentions | umls-concept:C0805586 | lld:lifeskim |
| pubmed-article:11168828 | lifeskim:mentions | umls-concept:C1883204 | lld:lifeskim |
| pubmed-article:11168828 | lifeskim:mentions | umls-concept:C0439828 | lld:lifeskim |
| pubmed-article:11168828 | lifeskim:mentions | umls-concept:C1880389 | lld:lifeskim |
| pubmed-article:11168828 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:11168828 | pubmed:dateCreated | 2001-2-22 | lld:pubmed |
| pubmed-article:11168828 | pubmed:abstractText | Following DNA immunization of rhesus macaques with a plasmid encoding the human immunodeficiency virus (HIV)-1 third variable domain (V3) loop, presented by pseudo-viral envelope particles of hepatitis B virus, specific immune responses were induced. The primates were then inoculated with a chimeric simian/human immunodeficiency virus (SHIV). All the animals were infected, but the V3-specific immunization provided a relative attenuation of the acute phase of infection in the absence of neutralizing antibody. In all animals, SHIV-specific cytotoxic T-lymphocyte precursors (CTLp) were detected early in peripheral blood and lymph nodes. The viremia peak correlated significantly with the decrease in CD4+ T cells and with a transient increase in the percentage of natural killer cells. The infection induced an oligoclonalization of the CD8+ T-cell variable beta chain repertoire in the blood. Surprisingly, HIV envelope-specific CTLp generated by genetic immunization may be governed by distinct circulation rules compared to SHIV-specific CTLp induced by infection. | lld:pubmed |
| pubmed-article:11168828 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11168828 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11168828 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11168828 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11168828 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11168828 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11168828 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11168828 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11168828 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11168828 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11168828 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:11168828 | pubmed:issn | 0047-2565 | lld:pubmed |
| pubmed-article:11168828 | pubmed:author | pubmed-author:JanvierGG | lld:pubmed |
| pubmed-article:11168828 | pubmed:author | pubmed-author:MichelM LML | lld:pubmed |
| pubmed-article:11168828 | pubmed:author | pubmed-author:AubertinA MAM | lld:pubmed |
| pubmed-article:11168828 | pubmed:author | pubmed-author:RivièreYY | lld:pubmed |
| pubmed-article:11168828 | pubmed:author | pubmed-author:DormontDD | lld:pubmed |
| pubmed-article:11168828 | pubmed:author | pubmed-author:VaslinBB | lld:pubmed |
| pubmed-article:11168828 | pubmed:author | pubmed-author:Le GrandRR | lld:pubmed |
| pubmed-article:11168828 | pubmed:author | pubmed-author:Le BorgneSS | lld:pubmed |
| pubmed-article:11168828 | pubmed:author | pubmed-author:BosonBB | lld:pubmed |
| pubmed-article:11168828 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11168828 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:11168828 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11168828 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11168828 | pubmed:pagination | 371-86 | lld:pubmed |
| pubmed-article:11168828 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11168828 | pubmed:meshHeading | pubmed-meshheading:11168828... | lld:pubmed |
| pubmed-article:11168828 | pubmed:meshHeading | pubmed-meshheading:11168828... | lld:pubmed |
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| pubmed-article:11168828 | pubmed:meshHeading | pubmed-meshheading:11168828... | lld:pubmed |
| pubmed-article:11168828 | pubmed:meshHeading | pubmed-meshheading:11168828... | lld:pubmed |
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| pubmed-article:11168828 | pubmed:meshHeading | pubmed-meshheading:11168828... | lld:pubmed |
| pubmed-article:11168828 | pubmed:meshHeading | pubmed-meshheading:11168828... | lld:pubmed |
| pubmed-article:11168828 | pubmed:meshHeading | pubmed-meshheading:11168828... | lld:pubmed |
| pubmed-article:11168828 | pubmed:meshHeading | pubmed-meshheading:11168828... | lld:pubmed |
| pubmed-article:11168828 | pubmed:meshHeading | pubmed-meshheading:11168828... | lld:pubmed |
| pubmed-article:11168828 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:11168828 | pubmed:articleTitle | Immune responses following simian/human immunodeficiency virus (SHIV) challenge of rhesus macaques after human immunodeficiency virus (HIV)-1 third variable domain (V3) loop-based genetic immunization. | lld:pubmed |
| pubmed-article:11168828 | pubmed:affiliation | Laboratoire d'Immunopathologie Virale, URA CNRS 1930, Institut Pasteur, Paris, France. riviere@pasteur.fr | lld:pubmed |
| pubmed-article:11168828 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11168828 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
