Linked Life Data

11168828

Source:http://linkedlifedata.com/resource/pubmed/id/11168828

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2001-2-22
pubmed:abstractText
Following DNA immunization of rhesus macaques with a plasmid encoding the human immunodeficiency virus (HIV)-1 third variable domain (V3) loop, presented by pseudo-viral envelope particles of hepatitis B virus, specific immune responses were induced. The primates were then inoculated with a chimeric simian/human immunodeficiency virus (SHIV). All the animals were infected, but the V3-specific immunization provided a relative attenuation of the acute phase of infection in the absence of neutralizing antibody. In all animals, SHIV-specific cytotoxic T-lymphocyte precursors (CTLp) were detected early in peripheral blood and lymph nodes. The viremia peak correlated significantly with the decrease in CD4+ T cells and with a transient increase in the percentage of natural killer cells. The infection induced an oligoclonalization of the CD8+ T-cell variable beta chain repertoire in the blood. Surprisingly, HIV envelope-specific CTLp generated by genetic immunization may be governed by distinct circulation rules compared to SHIV-specific CTLp induced by infection.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0047-2565
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
371-86
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:11168828-AIDS Vaccines, pubmed-meshheading:11168828-Animals, pubmed-meshheading:11168828-Antibodies, Viral, pubmed-meshheading:11168828-Blotting, Western, pubmed-meshheading:11168828-CD4 Lymphocyte Count, pubmed-meshheading:11168828-CD8-Positive T-Lymphocytes, pubmed-meshheading:11168828-Enzyme-Linked Immunosorbent Assay, pubmed-meshheading:11168828-HIV Envelope Protein gp120, pubmed-meshheading:11168828-HIV-1, pubmed-meshheading:11168828-Macaca mulatta, pubmed-meshheading:11168828-Peptide Fragments, pubmed-meshheading:11168828-Phenotype, pubmed-meshheading:11168828-Polymerase Chain Reaction, pubmed-meshheading:11168828-Simian Acquired Immunodeficiency Syndrome, pubmed-meshheading:11168828-Time Factors, pubmed-meshheading:11168828-Vaccines, DNA, pubmed-meshheading:11168828-Viral Load
pubmed:year
2000
pubmed:articleTitle
Immune responses following simian/human immunodeficiency virus (SHIV) challenge of rhesus macaques after human immunodeficiency virus (HIV)-1 third variable domain (V3) loop-based genetic immunization.
pubmed:affiliation
Laboratoire d'Immunopathologie Virale, URA CNRS 1930, Institut Pasteur, Paris, France. riviere@pasteur.fr
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't