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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2001-2-22
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pubmed:abstractText |
Multiple myeloma (MM) is a B-lineage malignancy with unknown aetiology. It has been considered that predisposing genetic factors might be implicated in the disease. In this study, the microsatellite polymorphism in the exon 3 of the cytotoxic T-lymphocyte antigen-4 (CTLA-4) gene was analysed in patients with MM and monoclonal gammopathy of undetermined significance (MGUS), together with ethnically matched healthy controls. The results showed that frequencies of the genotype 86/86 and of the allele 86 were significantly decreased in MM and MGUS compared with matched healthy controls, indicating that the CTLA-4 microsatellite polymorphism might represent a susceptibility locus for MM and MGUS.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0007-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
112
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
216-8
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11167807-Adult,
pubmed-meshheading:11167807-Aged,
pubmed-meshheading:11167807-Aged, 80 and over,
pubmed-meshheading:11167807-Antigens, CD,
pubmed-meshheading:11167807-Antigens, Differentiation,
pubmed-meshheading:11167807-CTLA-4 Antigen,
pubmed-meshheading:11167807-Case-Control Studies,
pubmed-meshheading:11167807-Female,
pubmed-meshheading:11167807-Gene Frequency,
pubmed-meshheading:11167807-Genetic Predisposition to Disease,
pubmed-meshheading:11167807-Genotype,
pubmed-meshheading:11167807-Humans,
pubmed-meshheading:11167807-Immunoconjugates,
pubmed-meshheading:11167807-Male,
pubmed-meshheading:11167807-Microsatellite Repeats,
pubmed-meshheading:11167807-Middle Aged,
pubmed-meshheading:11167807-Multiple Myeloma,
pubmed-meshheading:11167807-Paraproteinemias,
pubmed-meshheading:11167807-Polymorphism, Genetic,
pubmed-meshheading:11167807-Probability
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pubmed:year |
2001
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pubmed:articleTitle |
Cytotoxic T-lymphocyte antigen-4 microsatellite polymorphism is associated with multiple myeloma.
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pubmed:affiliation |
Division of Haematology, Department of Medicine, Karolinska Hospital and Karolinska Institutet, Stockholm, Sweden. Chengyun.Zheng@cmm.ki.se
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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